Development and characterisation of cellulose based electrospun mats for buccal delivery of non-steroidal anti-inflammatory drug (NSAID)

Nazari, Kazem; Kontogiannidou, Eleni; Ahmad, Rita Haj; Gratsani, Aggeliki; Rasekh, Manoochehr; Arshad, Muhammad Sohail; Sunar, Burde Suheyla; Armitage, David; Bouropoulos, Nikolaos; Chang, Ming Wei; Li, Xiang; Fatouros, Dimitrios G.; Ahmad, Zeeshan

doi:10.1016/j.ejps.2017.02.033

Cited by 48 publications

(38 citation statements)

References 30 publications

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“…The multiple peaks for the raw drug materials demonstrate that the drugs are crystalline in their original form. However, these peaks are no longer visible in the fibres' fingerprint due to the drugs converting to amorphous form and being distributed throughout the polymeric fibrous structure [24], which supports the findings realised in DSC. The peaks are also larger in the fibre profiles compared to raw PVP.…”

Section: Dsc Studiessupporting

confidence: 79%

“…It is clear from the results that the contact angle on INDO fibre samples decreased faster and to a lower value over 4 s from 54.55 to 8.26° compared to 88.15 to 28.01° with DICLO fibres. This suggests that the INDO fibres possessed greater wettability and hydrophilic properties than DICLO fibres [24], which may be due to differences in physical and chemical properties between INDO and DICLO. However, these peaks are no longer visible in the fibres' fingerprint due to the drugs converting to amorphous form and being distributed throughout the polymeric fibrous structure [24], which supports the findings realised in DSC.…”

Section: Contact Angle Measurementsmentioning

confidence: 97%

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Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches

et al. 2019

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The purpose of this study was to apply the Quality by Design (QbD) approach to the electrospinning of fibres loaded with the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin (INDO) and diclofenac sodium (DICLO). A Quality Target Product Profile (QTPP) was made, and risk assessments (preliminary hazard analysis) were conducted to identify the impact of material attributes and process parameters on the critical quality attributes (CQAs) of the fibres. A full factorial design of experiments (DoE) of 20 runs was built, which was used to carry out experiments. The following factors were assessed: Drugs, voltage, flow rate, and the distance between the processing needle and collector. Release studies exhibited INDO fibres had greater total release of active drug compared to DICLO fibres. Voltage and distance were found to be the most significant factors of the experiment. Multivariate statistical analytical software helped to build six feasible design spaces and two flexible, universal design spaces for both drugs, at distances of 5 cm and 12.5 cm, along with a flexible control strategy. The current findings and their analysis confirm that QbD is a viable and invaluable tool to enhance product and process understanding of electrospinning for the assurance of high-quality fibres.

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Section: Dsc Studiessupporting

confidence: 79%

Section: Contact Angle Measurementsmentioning

confidence: 97%

Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches

et al. 2019

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“…This process enables sensitive materials to be encapsulated within a polymeric fibrous matrix in a simple, one-step cost effective process [11]. It has already shown great promise in various pharmaceutical [12][13][14][15][16], food applications [17,18] and has recently gained interest in the cosmetic industry in perfumery [19,20] and FMs. For example, Camerlo et al [21] demonstrated the sustained release of limonene oil over 15 days by developing electrospun PVA fibers.…”

Section: Introductionmentioning

confidence: 99%

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

Mehta

Picken

White

et al. 2019

Intern J of Cosmetic Sci

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Introduction The stratum corneum is the biggest obstacle in cosmetics with respect to skin moisturisation. Many approaches have been taken to overcome the barrier, one of which is incorporating natural cosmeceuticals into cosmetic products to enhance moisturisation effects. Here, a commercial facemask formulation was electrospun to develop dry facemasks capable of hosting cosmeceuticals within the pores of incorporated mesoporous silica. Methods Ethanolic solutions containing 40% w/w of the marketed facemask (7th Heaven Dead Sea peel‐off facemask) and mesoporous silica were prepared and electrically processed at 30 μL min−1 at an applied voltage of 12 ± 2 kV. In vitro characterisation and release studies using fluorescein dye as a model probe were carried out. Results SEM images confirmed the fibrous nature of the resulting matrix; showing an average fiber diameter of 298.32 nm. The electrospun mask was found to be advantageous due to this fibrous nature providing high active loading capacity whilst demonstrating 100% probe release within 60 min. Contact Angle hysteresis, thermal analysis and Fourier Transform Infrared Spectroscopy (FTIR) presented evidence of compatibility and stability of and within the formulation. Conclusion Adapting the formulation of a commercial polymeric facemask into an electrospun facemask has shown the versatility of the electrospinning process; now successfully crossing over into the cosmetic industry.

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“…All formulated fibres exhibit a smooth surface; albeit with variable diameter distributions. The difference is attributed to the inclusion of additional excipients and co-polymer ratios [8]. Figure 5a).…”

Section: Fibre Morphology and Size Distributionmentioning

confidence: 99%

“…INDO is loaded directly into filamentous matrices [8] and previous studies report that a shift in the maximum temperature (associated weight-loss step) can be used to validate drug entrapment within films [51]. The thermal degradation of a composite formulation is also driven by the active ingredient (drug) used; as both increase and decrease in the maximum temperature associated weight loss have been shown [51].…”

Section: Tga Thermogram Of Pvp-indo Formulation (F1) Shows the Highesmentioning

confidence: 99%

Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

Nazari

Kontogiannidou

Ahmad

et al. 2017

European Polymer Journal

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Polymer based dosages form the mainstay of drug delivery systems either as simple matrix carrier materials or active release behaviour modulating agents. In addition, several techniques have been developed further to deliver novel polymeric structures. One such method is electrospinning (ES); a maturing process which is operational at the ambient environment and enables drug loading (in molecularly dispersed form) directly into a fibrous polymer matrix system. Since there is an impending need to address healthcare challenges arising from an increase in the aging population (requiring enhanced treatments), the ES method was used to develop fibrous polymer composite-indomethacin (

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Development and characterisation of cellulose based electrospun mats for buccal delivery of non-steroidal anti-inflammatory drug (NSAID)

Cited by 48 publications

References 30 publications

Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches

Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches

Engineering optimisation of commercial facemask formulations capable of improving skin moisturisation

Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

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