Development and applications of STIM- and PIXE-tomography: A review

Michelet, Claire; Barberet, Philippe; Moretto, Ph.; Seznec, Hervé

doi:10.1016/j.nimb.2015.08.070

Cited by 14 publications

(10 citation statements)

References 46 publications

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“…-Maximum Likelihood Expectation Maximization (MLEM), an iterative method based on a discrete formulation of the tomography problem, often used for PIXE tomography as a robust algorithm even with noisy and/or incomplete data [5,6,34]. The images presented here were obtained from 32 iterations, which was the optimal number determined from NAAD and NRSMD calculations (see section 2.8).…”

Section: Tomographic Reconstructionmentioning

confidence: 99%

“…For microscopic samples, pCT was developed using lower energy (a few MeV) accelerators. A review was published [2], giving historical aspects as well as technical details about experimental conditions and data reduction. To summarize the experimental procedure, the proton beam is focused using magnetic quadrupoles, down to a diameter from a few tens of nanometers up to a few micrometers, depending on the performances of the beam line and on the required beam intensity and/or spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

“…-Increasing data statistics and/or reducing beam time for PIXE, by increasing the detection solid angle, using two X-ray detectors at the same time [3,4]. -Correcting data for X-ray signal attenuation into the sample [3][4][5][6][7]. This attenuation is caused, first, by the variation of ionization cross section, which decreases due to the proton energy decrease into the sample, resulting in a decrease in X-ray production.…”

Section: Introductionmentioning

confidence: 99%

“…A second issue is X-ray absorption, which occurs into the sample, along the path from the emission points to the detector. An attempt to evaluate the accuracy of the reconstruction process for STIM and PIXE tomography was performed by comparing the results obtained from the same experimental data set, using different data reduction and tomographic reconstruction methods [3,5] compared to one another. A precise study would require using numerical phantoms of defined density and composition, in order to compare the reconstructed images with the original phantoms.…”

Section: Introductionmentioning

confidence: 99%

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A Geant4 simulation for three-dimensional proton imaging of microscopic samples

Michelet

Yang

et al. 2019

Physica Medica

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In these experiments, the samples are dehydrated for under vacuum analysis. In situ quantification of nanoparticles has been carried out at CENBG in the frame of nanotoxicology studies, on cells and small organisms used as biological models, especially on Caenorhabditis elegans (C. elegans) nematodes. Tomography experiments reveal the distribution of mass density and chemical content (in g.cm-3) within the analyzed volume. These density values are obtained using an inversion algorithm. To investigate the effect of this data reduction process, we defined different numerical phantoms, including a (dehydrated) C. elegans phantom whose geometry and density were derived from experimental data. A Monte Carlo simulation based on the Geant4 toolkit was developed. Using different simulation and reconstruction conditions, we compared the resulting tomographic images to the initial numerical reference phantom. A study of the relative error between the reconstructed and the reference images lead to the result that 20 protons per shot can be considered as an optimal number for 3D STIM imaging. Preliminary results for PIXE tomography are also presented, showing the interest of such numerical phantoms to produce reference data for future studies on X-ray signal attenuation in thick samples.

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Section: Tomographic Reconstructionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Geant4 simulation for three-dimensional proton imaging of microscopic samples

Michelet

Yang

et al. 2019

Physica Medica

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“…To do the ZAF correction all of the elemental tomographs need to be known, and they are not independent of each other! However, after much effort PIXE-T is now also a solved problem: 198 it has been demonstrated for hair 199 (and other targets too: see the useful review of STIM-T and PIXE-T by Michelet et al 200 ).…”

Section: Analystmentioning

confidence: 99%

Thin film depth profiling by ion beam analysis

Jeynes

Colaux

2016

Analyst

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The analysis of thin films is of central importance for functional materials, including the very large and active field of nanomaterials. Quantitative elemental depth profiling is basic to analysis, and many techniques exist, but all have limitations and quantitation is always an issue. We here review recent significant advances in ion beam analysis (IBA) which now merit it a standard place in the analyst's toolbox. Rutherford backscattering spectrometry (RBS) has been in use for half a century to obtain elemental depth profiles non-destructively from the first fraction of a micron from the surface of materials: more generally, "IBA" refers to the cluster of methods including elastic scattering (RBS; elastic recoil detection, ERD; and non-Rutherford elastic backscattering, EBS), nuclear reaction analysis (NRA: including particle-induced gamma-ray emission, PIGE), and also particle-induced X-ray emission (PIXE). We have at last demonstrated what was long promised, that RBS can be used as a primary reference technique for the best traceable accuracy available for non-destructive model-free methods in thin films. Also, it has become clear over the last decade that we can effectively combine synergistically the quite different information available from the atomic (PIXE) and nuclear (RBS, EBS, ERD, NRA) methods. Although it is well known that RBS has severe limitations that curtail its usefulness for elemental depth profiling, these limitations are largely overcome when we make proper synergistic use of IBA methods. In this Tutorial Review we aim to briefly explain to analysts what IBA is and why it is now a general quantitative method of great power. Analysts have got used to the availability of the large synchrotron facilities for certain sorts of difficult problems, but there are many much more easily accessible mid-range IBA facilities also able to address (and often more quantitatively) a wide range of otherwise almost intractable thin film questions.

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A Geant4 simulation of X-ray emission for three-dimensional proton imaging of microscopic samples

Michelet

Jalenques

et al. 2022

Physica Medica

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Development and applications of STIM- and PIXE-tomography: A review

Cited by 14 publications

References 46 publications

A Geant4 simulation for three-dimensional proton imaging of microscopic samples

A Geant4 simulation for three-dimensional proton imaging of microscopic samples

Thin film depth profiling by ion beam analysis

A Geant4 simulation of X-ray emission for three-dimensional proton imaging of microscopic samples

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