Development and application of UHPLC–MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts

Nováková, Lucie; Vildová, Anna; Mateus, Joana Patricia; Gonçalves, Tiago; Solich, Petr

doi:10.1016/j.talanta.2010.06.057

Cited by 100 publications

(66 citation statements)

References 16 publications

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“…In contrast, infusions of S. cerulea (34.09 mg 100 g -1 DW) were characterized by 16.5-to 19.6-fold lower contents of quercetin derivatives compared to the previously mentioned samples. Comparatively high levels of quercetin derivatives have been quantified in chamomile tea (Nováková et al, 2010). In contrast, Raal et al (2012) reported their share in a range from 0.29% to 1.21% TAPs in infusions from commercial German chamomile.…”

Section: Resultsmentioning

confidence: 98%

Phenolic compounds in floral infusions of various Sambucus species and their interspecific hybrids

Todorović¹,

Mikulič-Petkovšek²,

Štampar³

et al. 2017

Turk J Agric For

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associated with yield (number and size of inflorescences), chemical composition of inflorescences, growth characteristics, uniformity of flowering, and resistance to pests and diseases. Our studies indicate that interspecific hybridization efficiently increases the variation in the chemical composition of elderberry fruits (Mikulic-Petkovsek et al., 2014.Polyphenolic compounds are regarded as important chemical compounds due to their high antioxidant efficacy (Ozgen et al., 2010), which has a positive impact on people's health, and may impede the development of cancer and inhibit oxidative damage (Akbulut et al., 2009). Phenolic compounds possess various pharmacological effects: antiviral, antibacterial, antiinflammatory, and anticancer functions. Positive effects of flavonoids and phenolic acids have also been reported in connection with cardiovascular diseases (Olthof et al., 2001;Netzel et al., 2002;Murkovic et al., 2004). It has been reported that the concentration of phenolics is closely connected with the antioxidant activity of plant tissue and thus an assessment of the phenolic profile is important for the determination of antioxidant capacity (Choi and Kwak, 2014). The antioxidant activity of elderberry inflorescence extracts ranged from 44.8 to 118.2 mM TE/kg DW (Mikulic-Petkovsek et al., 2016).

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Section: Resultsmentioning

confidence: 98%

Phenolic compounds in floral infusions of various Sambucus species and their interspecific hybrids

Todorović¹,

Mikulič-Petkovšek²,

Štampar³

et al. 2017

Turk J Agric For

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“…German chamomile contains several classes of biologically active compounds including essential oils (Granzera, Schneider, & Stuppner, 2006;Petronilho, Maraschin, Coimbra, & Rocha, 2012) and several polyphenols (McKay, & Blumberg, 2006;Nováková, Vildová, Mateus, Gonçalves, & Solich, 2010). Some phenolic compounds have the capacity to quench lipid peroxidation products, prevent DNA oxidative damage, and scavenge reactive oxygen species (ROS) such as superoxide, hydrogen peroxide and hydroxyl radicals (Kahkonen et al, 1999).…”

Section: Introdutionmentioning

confidence: 99%

“…Some related studies dealing with M. recutita flowers are available in literature, including reports on antioxidant properties of its methanol extract (Barros, Oliveira, Carvalho, & Ferreira, 2010;Miliauskas, Venskutonis, & Beek, 2004), antitumour potential of aqueous and organic extracts (Strivastava & Gupta, 2007;Strivastava & Gupta, 2009), and phenolic composition of methanolic extracts (Mulinacci, Romani, Pinelli, Vincieri, & Prucher, 2000;Nováková et al, 2010). Nevertheless, studies on M. recutita infusion and decoction, the most consumed preparation of this herb, are scarce, and therefore, the present study reports the bioactive properties (antioxidant and antitumour activities, and hepatotoxicity), organic acids and phenolic characterization of wild M. recutita infusions and decoction (the most consumed preparations of this herb).…”

Section: Introdutionmentioning

confidence: 99%

Infusion and decoction of wild German chamomile: Bioactivity and characterization of organic acids and phenolic compounds

et al. 2013

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Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in drug discovery. Herein, methanol extract of Matricaria recutita L. (German chamomile) and its decoction and infusion (the most consumed preparations of this herb) were submitted to an analysis of phytochemicals and bioactivity evaluation. The antioxidant activity was determined by free radicals scavenging activity, reducing power and inhibition of lipid peroxidation; the antitumour potential was tested in human tumour cell lines (breast, lung, colon, cervical and hepatocellular carcinomas), and the hepatotoxicity was evaluated using a porcine liver primary cell culture (non-tumour cells). All the samples revealed antioxidant properties. Decoction had no antitumour activity (GI 50 >400 µg/mL) which could indicate that this bioactivity might be related to compounds (including phenolic compounds) that were not extracted or that were affected by the decoction procedure.Both plant methanol extract and infusion showed inhibitory activity of the growth of HCT-15 (GI 50 250.24 and 298.23 µg/mL, respectively) and HeLa (GI 50 259.36 and 277.67 µg/mL, respectively) cell lines, without hepatotoxicity (GI 50 >400 µg/mL).Infusion and decoction gave higher contents of organic acids (24.42 and 23.35 g/100 g dw). Otherwise, the plant methanol extract presented the highest amounts of phenolic acids (3.99 g/100 g dw) and flavonoids (2.59 g/100 g dw). The major compound found in all the preparations was luteolin O-acylhexoside. Overall, German chamomile contains important phytochemicals with bioactive properties (mainly antitumour potential selective to colon and cervical carcinoma cell lines) to be explored in the medicine, food, and cosmetic industries.

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“…Methanolic extracts of M. recutita flowers and tea contain high amounts of the flavonoids apigenin and luteolin (Fig. 1), as well as the coumarin umbelliferone (7-hydroxycoumarin) (Novakova et al, 2010). (−)-α-Bisabolol (Fig.…”

Section: Introductionmentioning

confidence: 99%

Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels

Roberts

Allen

Chang

et al. 2013

Toxicology and Applied Pharmacology

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Development and application of UHPLC–MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts

Cited by 100 publications

References 16 publications

Phenolic compounds in floral infusions of various Sambucus species and their interspecific hybrids

Phenolic compounds in floral infusions of various Sambucus species and their interspecific hybrids

Infusion and decoction of wild German chamomile: Bioactivity and characterization of organic acids and phenolic compounds

Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels

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