Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential

Abstract

Carbon quantum dots (CQDs) derived from natural sources have obtained potential interest in biomedical imaging and therapy because of their excellent biocompatibility properties, which include water solubility, simple synthesis and low cytotoxicity. Here the cytotoxicity of ethylene‐diamine doped carbon quantum dots (N‐CQDs) delivered to breast cancer MCF‐7 cells was investigated. Folic acid was used to raise folate recognition and increase FA‐NCQD accumulation in the cells, then apoptosis was assayed using nuclear fragmentation, acridine orange labeling, fluorescence imaging, flow cytometry, and caspase 3 expression. The data show that functionalization of these CQDs, derived from a natural source, have potential application in eliminating cancer cells, as shown here for the invasive breast cancer cells, MCF‐7. This nano‐delivery system provides a novel target therapy possibility therapeutic approach for cancer cells.

Simultaneous Administration of Bevacizumab with Bee-Pollen Extract-Loaded Hybrid Protein Hydrogel NPs Is a Promising Targeted Strategy against Cancer Cells

“…EPCIBP exhibited a homogenous distribution of negatively charged particles with a diameter of 116 nm. Folic-acid-conjugated PRM was characterized by the presence of its two main peaks at 285 nm and 365 nm in the spectrum of EPCIBP ( Figure 2 , Figure 3 and Figure 4 ) [ 34 ].…”

“…The mixture was then agitated for 1 h at 55 °C and 200 rpm using a magnetic stirrer. The supernatant was removed by centrifugation for 10 min at 6000 rpm [ 34 ]. After that, the supernatant was kept at 4 °C until it was used.…”

Preparation, Physicochemical, and Cyto- and Genotoxic Characterisation of Polysaccharide Composites Containing Carbon Quantum Dots

“…The ongoing research developments that are leading to an increasing control over the synthesis and properties of carbon dots are opening up a multitude of new application opportunities for them. Currently, the greatest potential of carbon dots is seen in sectors related to biotechnology, medicine, and the food industry [ 15 , 20 , 21 , 22 ].…”