Development and Application of Liquid Chromatography in Life Sciences

Abstract

Liquid chromatographic approaches cover a wide range of applications today. It is closely relevant in scientific studies, which provides a powerful identification of certain components that will be effective for curing specific diseases. Especially important, LC methods can assist us for isolation and purification of therapeutic drugs that benefit for the development of medical industry. As the development of liquid chromatography, the single effective component within a drug can be separated and purified under extreme purity requirements from a biological system with great complexity and abundance. However, improvement of LC methods is still urgently needed for better application of this method to benefit our lives.

Review on analytical methods for quantification of ADHD drugs in human biological samples

“…The samples are separated based on their affinities towards the stationary phase and detected using various detectors (including UV-Vis, DAD and fluorescence). Currently, LC using reversed-phase silica columns is preferred for pharmaceutical analysis [83].…”

Theoretical Analysis of a Nonequilibrium Transport Model of Two-Dimensional Nonisothermal Reactive Chromatography Accounting for Bi-Langmuir Isotherm

“…The ongoing progress in science and technology has further revolutionized this process. 1 This technique can be effectively applied to targeted separation tasks for producing high-purity products at economical production rates. Chromatography is frequently applied as a separation and purification technique in fine chemical, petrochemical, biotechnical, pharmaceutical, forensic pathology, nucleic acid research, and many more areas.…”

“…Among the aforementioned techniques, chromatography is an efficient, accurate, and effective technique used in industries and laboratories to separate and analyze different kinds of complex chemical mixtures. The ongoing progress in science and technology has further revolutionized this process . This technique can be effectively applied to targeted separation tasks for producing high-purity products at economical production rates.…”

Editor's Note: Journal of Chromatography and Separation Techniques

“…Zhu's [2] study aims to review the origin and the development of this analytical tool from a historical perspective by highlighting its application in life sciences. The study discussed the role of Liquid chromatography in isolating and purifying therapeutic drugs that benefit the humanity.…”