Abstract:<p>In this manuscript we address an important gap in our
current carbohydrate active enzyme toolbox, by developing a highly a2,6-selective (over a2,3-selective) de facto sialidase that is necessary
both for glycan analysis and glycoconjugate remodeling. Both glycosidic linkages
are commonly found in animal biology and each has been shown to have distinct
biological function.</p>
<p>Our approach is novel in that it harnesses the high
selectivity of known glycosyltransferases ‘in reverse’ fo… Show more
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