Spray combustors are now widely used in many technologies, spanning commodity chemical synthesis (combustion of molten sulfur en route to sulfuric acid (H 2 SO 4 ) and phosphorus en route to phosphoric acid (H 3 PO 4 ), ...), and nanoparticle synthesis (eg., via "spray pyrolysis"), to energy conversion (oil-fired furnaces or boilers) and chemical propulsion (aircraft gas turbines and liquid-propellant rocket motors). While important space, weight, and pollutant constraints inevitably differ from application to application, spray-"fuel"-fed combustors share certain common performance characteristics, and there is a considerable economic incentive to develop rational yet tractable design methods for them. While this intrinsically interdisciplinary subject continues to evolve, here, we briefly review some of the principal contributions to these challenging goals published by chemical engineers since the inception of Industrial and Engineering Chemistry (I&EC). Not surprisingly, the earliest contributions focused on some of the important "unit processes" (e.g., isolated droplet evaporation rates, vapor micromixing rates in spatially homogeneous turbulent flows, and steady vaporphase laminar diffusion flames). Chemical engineers introduced "continuous mixture theory" to economically address not only phase/chemical equilibria in multicomponent mixtures, but also spatially nonuniform (nonequilibrium) flows. More-recent studies have introduced diffusion "flamelet" concepts for vapor-phase nonpremixed combustion and statistical population-balance concepts to address evolving turbulence characteristics and/or droplet size distributions. Because of the wide range of operative (length and time) scales in the full problem, in the foreseeable future, clever asymptotic methods will continue to be required to capture the essential physicochemical phenomena but still make the associated numerical simulations manageable. In this regard, a fruitful unified perspective is now emergingsone quite natural to chemical engineers. This can perhaps be best described as an interacting "multi-phase, multi-environment" approachsor simply an "interacting multivariable population balance" approach. While much remains to be done, it is hoped that this 2008/2009 perspective, and highly selective "review" of but one class of multiphase chemical reactors, will stimulate further activity along this promising path.