Developing Novel Spinning Methods to Fabricate Continuous Multifunctional Fibres for Bioapplications

Mirabedini, Azadeh

doi:10.1007/978-3-319-95378-6

Cited by 14 publications

(49 citation statements)

References 123 publications

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“…These scaffolds and stimuli are tailored for specific tissue growth and applications and therefore can vary greatly. A wide range of materials are known to be utilized as cell supporting materials in biomedical applications including natural and synthetic polymers, metals, ceramics and alloys [1]. Aside from the specific materials used in certain applications such as orthopedics, dental implants and artificial vascular materials, the focus of this chapter is on the role of naturally occurring hydrogels to develop biofibres with the final use as biocompatible templates for the purpose of drug delivery systems or the building blocks of tissue scaffolds.…”

Section: Materials Considerations For Biomedical Applicationsmentioning

confidence: 99%

“…Polysaccharides are a typical group of natural biopolymers showing great swellability that make them ideal candidates for preparing hydrogels. Polysaccharides are high molecular weight polymeric carbohydrates formed from repeating monosaccharide units [1]. Polysaccharides are advantageous for biomedical applications due to their wide availability, low cost as well as the presence of functional groups in the polymer chain.…”

Section: Natural Hydrogelsmentioning

confidence: 99%

“…Alginate and chitosan are considered as the most extensively used gel-forming polysaccharides for cell growth from natural sources. They were chosen and used in this study mainly due to their several unique properties including biodegradability, biocompatibility, low toxicity, promoting attachment, migration, proliferation and differentiation of cells and antimicrobial activity as well as ease of fabrication and availability [1].…”

Section: Natural Hydrogelsmentioning

confidence: 99%

“…Salts of alginic acid with monovalent cations such as sodium alginate are all soluble in water and capable of holding a large amount of water. Alginate has been extensively used as a scaffold for liver, bone, nerve and cartilage engineering [1]. Even though, alginates are non-toxic and biocompatible, using them for biomedical applications has several drawbacks.…”

Section: Sodium Alginatementioning

confidence: 99%

“…Chitosan is a semi-crystalline natural polysaccharide [1] with a totally different nature than that of alginate which has recently generated great interest for its potential in clinical and biological applications such as artificial skin, tissue engineering and controlled drug delivery. The cationic polymer chitosan originates from crustacean skeletons [13].…”

Section: Chitosanmentioning

confidence: 99%

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Hydrogels Fibers

Foroughi¹,

Mirabedini²

2018

Hydrogels

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With the ever increasing demand for suitable tissue engineering and drug delivery systems, hydrogel fiber spinning has drawn increasing attention due to its ability to create threedimensional (3D) structures using biomaterials. Hydrogel materials have shown a great promise to be used as templates for tissue engineering and implantable devices. Among the many production techniques available, advanced fiber processing, such as coaxial and triaxial spinning of natural hydrogels, has attracted a great deal of attention because the basic core-sheath structure provides a drug delivery system capable of delivering high concentrations of drug for localized drug delivery and tissue engineering applications. Encapsulating the drug and bioactive cores with a more bio-friendly coating allows for a versatile system for producing devices with appropriate mechanical, chemical and biological properties that can mimic the native extracellular matrix, better supporting cell growth and maintenance. This chapter presents a novel fabrication method using a wet-spinning process that allows for the routine production of multifunctional coaxial hydrogel fibers that take advantage of the encapsulating properties of a hydrogel core while also promoting good cell growth and biocompatibility via the use of bio-friendly material in the sheath.

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Section: Materials Considerations For Biomedical Applicationsmentioning

confidence: 99%

Section: Natural Hydrogelsmentioning

confidence: 99%

Section: Natural Hydrogelsmentioning

confidence: 99%

Section: Sodium Alginatementioning

confidence: 99%

Section: Chitosanmentioning

confidence: 99%

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Hydrogels Fibers

Foroughi¹,

Mirabedini²

2018

Hydrogels

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Evolving Strategies for Producing Multiscale Graphene‐Enhanced Fiber‐Reinforced Polymer Composites for Smart Structural Applications

et al. 2020

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Graphene has become an important research focus in many current fields of science including composite manufacturing. Developmental work in the field of graphene‐enhanced composites has revealed several functional and structural characteristics that promise great benefits for their use in a broad range of applications. There has been much interest in the production of multiscale high‐performance, lightweight, yet robust, multifunctional graphene‐enhanced fiber‐reinforced polymer (gFRP) composites. Although there are many reports that document performance enhancement in materials through the inclusion of graphene nanomaterials into a matrix, or its integration onto the reinforcing fiber component, only a few graphene‐based products have actually made the transition to the marketplace. The primary focus of this work concerns the structural gFRPs and discussion on the corresponding manufacturing methodologies for the effective incorporation of graphene into these systems. Another important aspect of this work is to present recent results and highlight the excellent functional and structural properties of the resulting gFRP materials with a view to their future applications. Development of clear standards for the assessment of graphene material properties, improvement of existing materials and scalable manufacturing technologies, and specific regulations concerning human health and environmental safety are key factors to accelerate the successful commercialization of gFRPs.

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