Developing Nanostructured Metals for Manufacturing of Medical Implants with Improved Design and Biofunctionality

Valiev, Ruslan Z.; Парфенов, Е.В.; Parfenova, Lyudmila V.

doi:10.2320/matertrans.mf201943

Cited by 30 publications

(13 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases, the enhancement of fatigue properties in UFG metals relates to an increase in YS as a result of grain refinement. [71] The dependence of fatigue endurance limit (σ R ) on grain size (d) is often described by a ratio similar to the Hall-Petch equation: 5 , where σ iR and K R are material constants. The potential to enhance fatigue properties in UFG Ti-6Al-4V ELI by the combination of ECAP and extrusion has been shown.…”

Section: Fatigue Propertiesmentioning

confidence: 99%

“…For example, recent reviews mention previously developed and widely known methods of high-pressure torsion (HPT) and equal channel angular pressing (ECAP), as well as multi-directional forging, accumulative roll bonding, constrained groove pressing, twist extrusion, etc. [5][6][7] As for titanium alloys, which are classified as hard-to-deform materials, SPD is usually applied to them at elevated temperatures. The majority of studies are dedicated to SPD techniques such as HPT, multi-directional forging, and ECAP.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, an increased activity toward the development of existing methods and creation of new schemes of SPD has been observed. For example, recent reviews mention previously developed and widely known methods of high‐pressure torsion (HPT) and equal channel angular pressing (ECAP), as well as multi‐directional forging, accumulative roll bonding, constrained groove pressing, twist extrusion, etc …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrafine‐Grained Titanium‐Based Alloys: Structure and Service Properties for Engineering Applications

et al. 2019

View full text Add to dashboard Cite

Herein, an overview of the recent research on the relationship between the ultrafine‐grained (UFG) structure of titanium and its alloys and the physical and mechanical properties of the materials, as well as the formation of advanced functional and service properties, including fatigue strength, creep behavior, and impact and fracture toughness is presented. It is shown that due to the record properties achieved in UFG titanium and its alloys, these materials have an innovative potential for successful application in medicine and engineering industries. Some of these works are carried out in cooperation with the team of Prof. Terence G. Langdon. Professor Langdon made a significant contribution to the development of modern materials science in the field of nanostructured metallic materials.

show abstract

Section: Fatigue Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrafine‐Grained Titanium‐Based Alloys: Structure and Service Properties for Engineering Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The difficulty in chemical modification or synthesis of HA derivatives is due to intermolecular entanglement, and complications associated with the control of viscoelasticity and molecular weight properties. A general method for inducing chemical modification to HA involves using a carboxylic acid (COOH) and an alcohol (OH) functional groups that are present in a repeating unit of a polymer or a physical method by using a carboxylic acid anion charge [28]. Recently, Deng et al [29] reacted chitosan (CS) and HA by modifying both natural polymers chemically to form hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid and Controlled Release: A Review

2020

View full text Add to dashboard Cite

Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

show abstract

“…107) There has been significant progress in recent years on the structural properties of severely-deformed materials such as hardness, 34) strength/ductility 30) and creep 35) as well as on the functional properties such as superconductivity, 40,41) thermoelectric performance, 45) radiation resistance, 44) photocatalytic activity, 37) hydrogen storage, 42,43) corrosion resistance 38) and biocompatibility. 39) Among all these properties, the biocompatibility appears to be the most attractive functional properties for commercialization of SPD process. 71,108) For the structural properties, the achievement of room-temperature superplasticity in magnesium and aluminum alloys for the first time is one the most innovative results reported recently.…”

mentioning

confidence: 99%

Severe Plastic Deformation for Nanostructure Controls

Horita

Edalati²

2020

Mater. Trans.

View full text Add to dashboard Cite

This paper presents a current research trend for micro-and nano-structure controls using severe plastic deformation (SPD). The survey is carried out based on the special issue published in July and August, 2019, in Materials Transactions (Vol. 60, Nos. 7 and 8). The SPD-related research is rapidly growing particularly after the year 2000. The research ranges over processing, modeling, simulation, synthesis, characterization and evaluation. Among the various topics, a brief introduction is given for innovative approaches which will further promote the development of the SPD-related research.

show abstract

Developing Nanostructured Metals for Manufacturing of Medical Implants with Improved Design and Biofunctionality

Cited by 30 publications

References 123 publications

Ultrafine‐Grained Titanium‐Based Alloys: Structure and Service Properties for Engineering Applications

Ultrafine‐Grained Titanium‐Based Alloys: Structure and Service Properties for Engineering Applications

Hyaluronic Acid and Controlled Release: A Review

Severe Plastic Deformation for Nanostructure Controls

Contact Info

Product

Resources

About