Developing Formulations of Prebiotics and Probiotics

Ahire, Eknath D.; Sharma, Neeraj; Gupta, Prakash C.; Khairnar, Shubham J.; Surana, Khemchand R.; Ahire, Bhavana; Sonawane, Vijayraj; Laddha, Umesh; Sonkamble, Sneh; Sabale, Rahul; Kshirsagar, Sanjay J.

doi:10.1002/9781394167227.ch10

Cited by 12 publications

(7 citation statements)

References 61 publications

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“…Dried Proliposomes were collected and stored at -18°C in a glass jar that kept air out so they could be used in further studies. Table 1 shows the formulation of proliposomes (Ahire et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

Proliposomal Dry Powder Inhalation: Design and Development for Pulmonary Antihypertensive Drug Delivery

Kumar,

Gurinderdeep,

Dhruv

et al. 2024

Intern. J. Zool. Invest.

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The present study aimed to create a dry powder proliposomal inhaler that would administer a medication for hypertension to the lungs. The pulmonary method of administration also has many benefits because the alveolar membrane is very thin and highly permeable, which lets different APIs be absorbed by the lungs. After getting information from the in vitro drug penetration, RSM analysis was used to find out how each measure affected the results. The best mix of cholesterol and soya phosphatidylcholine (SPC) was picked from the different amounts. Five grammes of SPC, six grammes of cholesterol, and a stirring speed of 210 rpm (F5) were picked as the amounts. It shows 94.81% in vitro permeability for 12 h with the improved preparation. Several different kinetic models are used to display the drug release kinetics data from in vitro drug release research. We were able to comprehend the drug's release mechanism thanks to the curve fitting findings of the generated formulae' rate of entrance. We employed non-Fickian diffusion to account for the medication release. Based on the "n" number of 0.6300, this suggested both a diffusion and growth process. Also, Higuchi gave the best answer for how the drug was released, as shown by the plots' highest level of regularity (r2 = 0.9990) and Higuchi's best fit for the drug release. In the improved composition, particles with a size of 683 nm were seen. Based on the above findings, atenolol proliposomes show potential as a way to give medicine to treat high blood pressure.

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Section: Methodsmentioning

confidence: 99%

Proliposomal Dry Powder Inhalation: Design and Development for Pulmonary Antihypertensive Drug Delivery

Kumar,

Gurinderdeep,

Dhruv

et al. 2024

Intern. J. Zool. Invest.

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“…Plotting average peak areas versus sample concentrations allowed for the linear connection to be verified in accordance with the technique validation process (Table 1). For DST, it was assessed over a range of 10-22 ppm (Ahire et al, 2022(Ahire et al, , 2023.…”

Section: Linearity and Rangementioning

confidence: 99%

RP-HPLC Technique for Dustasteride Quantitative Estimation in Tablet Dosage Form: Formulation and Validation of Analytical Technique

Rajaram,

Erattil

et al. 2024

Intern. J. Bio. Env. Invest.

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RP-HPLC is a novel analytical technique that can be used to detect dutasteride in pharmaceutical formulations and bulk pharmaceuticals. The aim of developing this technique was to provide an analytical RP HPLC method based on the Shiseido C18 analytical column that is accurate, dependable, and analytical for determining the concentration of dutasteride in both bulk and single component forms. The phase of mobile phase MeOH: ACN: H2O ratio was 75:10:15 (V/V/V) at a UV detector wavelength of 274 nm, and the flow rate remained constant at 0.7 ml/min. At 8:34 min, the dutasteride case was concluded amicably. The run lasted 10 min, with the temperature remaining at 20°C. Tests were conducted to ensure that the recently developed analytical RP-HPLC technology satisfies the reliability requirements. In compliance with the ICH Revised Q2 (R1) guidelines for analytical technique validation, it was verified. The analytical technique's method features demonstrated its ability to maintain its sensitivity, accuracy, precision, selectivity, and consistency throughout time. A straight line relationship between the concentration range of 10 to 22 ppm was displayed in the calibration plot. 5.3010 µg/ml was the LOQ, while 10.999 µg/ml was the LOD. The drug's consistency test indicated that the procedure is most likely rather excellent. Reliability tests revealed that the %RSD was within allowable bounds. The authorised technique quantified dutasteride in pharmaceutical formulations and bulk drugs satisfactorily.

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“…Nanoparticles have the potential to improve cancer treatment by facilitating the detection of cancer cells, the delivery of multiple drugs at once, the visualization of the treatment site with imaging agents, the destruction of cancer cells with minimal side effects, and the simultaneous monitoring and treatment of the patient. [71][72][73]…”

Section: Shortcoming Limitations and Future Prospects Of Nanocarriersmentioning

confidence: 99%

The emergence of nanocarriers in the management of diseases and disorders

Khulbe

Singh

Aman

et al. 2023

Community Acquir Infect

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Drugs can be delivered using oral nanocarriers in controlled, site-specific releases. Target receptors are physically, chemically, and biologically conjugated while administering a specific medicine. Since micro carriers have a 200 nm width, nanomedicine typically refers to objects with that size. Drugs can be delivered by nanocarriers to parts of the body that are inaccessible. Nanocarriers cannot deliver large pharmaceutical dosages due to their small size. Emulsion-based nanocarriers often have poor drug loading and encapsulation, which restricts their potential for therapeutic use. Various therapeutic nanocarriers exist. Ultrabright nanocarriers, polymeric nanocarriers, smart nanocarriers, nanocomposites, protein nanocarriers, nucleic acid-based nanocarriers, carbon nanotubes, and nanobubbles are examples of novel nanocarriers. All of them have successfully treated cancer. This review looks at targeted drug delivery methods and nanocarriers.

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Developing Formulations of Prebiotics and Probiotics

Cited by 12 publications

References 61 publications

Proliposomal Dry Powder Inhalation: Design and Development for Pulmonary Antihypertensive Drug Delivery

Proliposomal Dry Powder Inhalation: Design and Development for Pulmonary Antihypertensive Drug Delivery

RP-HPLC Technique for Dustasteride Quantitative Estimation in Tablet Dosage Form: Formulation and Validation of Analytical Technique

The emergence of nanocarriers in the management of diseases and disorders

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