Developing evaluation method for peripheral sensitization in cultured sensory neurons
Yuki Miyahara,
Kenta Shimba,
Kiyoshi Kotani
et al.
Abstract:Peripheral sensitization, decrease in pain threshold in sensory neurons, can cause chronic pain. Little is known about how peripheral sensitization led to chronic pain. Here, we aimed to develop a method for evaluating peripheral sensitization in cultured sensory neurons with electrical recording. Sensory neurons from rat dorsal root ganglion were cultured on high‐density microelectrode arrays (HD‐MEA), and their activity was evoked by capsaicin stimulation with or without substance P. Fluorescent imaging‐base… Show more
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