Developing brain as a source of circulating norepinephrine in rats during the critical period of morphogenesis

Муртазина, А. Р.; Nikishina, Yu. O.; Бондаренко, Н. С.; Dil’mukhametova, L. K.; Sapronova, A. Ya.; Ugrumov, M. V.

doi:10.1007/s00429-019-01950-5

Cited by 1 publication

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these data cannot serve as direct evidence that the brain is the only source of CSF monoamines. Indeed, we cannot exclude that monoamines enter the CSF not only from the brain neurons but from the bloodstream as well in the absence of a blood–brain barrier for monoamines in the perinatal period [ 14 , 29 , 30 ], with also taking into account the possibility of a metabolism between the CSF and blood in the choroid plexus in the lateral ventricles, in circumventricular organs, and the area of the caudal venous sinus even in adult animals [ 7 ]. In addition, one should not forget the fact that there are such important sources of monoamines as the adrenal glands, gastrointestinal tract, and the peripheral sympathetic nervous system [ 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of CSF and the Blood Levels of Monoamines As Neurohormones in Rats during Ontogenesis

et al. 2021

Self Cite

View full text Add to dashboard Cite

According to the literature, the cerebrospinal fluid (CSF) in the cerebral ventricles contains numerous neuron-derived physiologically active substances that can function as neurohormones and contribute to volume neurotransmission in the periventricular region of the brain. This study was aimed at carrying out a comparative analysis of CSF and the blood levels of monoamines in rats during ontogenesis as an indicator of age-related characteristics of monoamine transport to body fluids and their function as neurohormones in volume neurotransmission in the periventricular region of the brain. We have shown that CSF in the perinatal period and adulthood contains the most functionally significant monoamines: dopamine, noradrenaline, and serotonin. A comparison of the monoamine levels in the CSF and blood of animals of different age groups revealed that CSF contains monoamines of predominantly neuronal (cerebral) origin and almost no monoamines derived from the general circulation. We also established that monoamines are found in the CSF at physiologically active levels that allow them to act as neurohormones in both reversible volume neurotransmission in the adult brain and irreversible regulation of brain development in the perinatal period.

show abstract