Developing and downscaling a method by HILIC coupled simultaneously to ESIMS and ICPMS to determine the affinity of lanthanide chelating molecules using specific isotope dilution

Abstract

A new method of HILIC coupled to ESIMS and ICPMS, combined with online specific isotopic dilution has been developed and downscaled to determine the affinity of hydrophilic molecules towards natSm and natNd.

Atomic spectrometry update: review of advances in elemental speciation

“…This approach and analytical work ow is clearly of great importance in the nuclear reprocessing industry. To this end, a study on the binding of radionuclides with different model ligands, 117 has produced a useful reference work, investigating a wide ranging assortment of HILIC columns (21 in total) of varying dimensions, including standard, nano and capillary (2.1, 0.3 and 0.075 mm id, respectively), with different types of mainly silica support phases for different functional stationary phases (7 in total). Specic isotope dilution was also used as a method of quantication for the determination of the affinity and selectivity of three structurally complex chelating molecules towards lanthanides used as model non-radioactive elements.…”