Developing an international consensus on DDT: a balance of environmental protection and disease control

Walker, Kathleen; Ricciardone, Marie D.; Jensen, Janice King

doi:10.1078/1438-4639-00239

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…The combination of public health benefits and environmental risks associated with DDT has made use of the pesticide controversial (Walker et al 2003). DDT was once used extensively throughout the world, for both agricultural and public health purposes [Agency for Toxic Substances and Disease Registry (ATSDR) 2002].…”

mentioning

confidence: 99%

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

Gladen

Klebanoff

Hediger

et al. 2004

Environ Health Perspect

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DDT (dichlorodiphenyltrichloroethane), a pesticide once used widely in agriculture and now limited to public health use, remains a controversial chemical because of a combination of benefits and risks. DDT or its breakdown products are ubiquitous in the environment and in humans. Compounds in the DDT family have endocrine actions and have been associated with reproductive toxicity. A previous study reported associations between prenatal exposure to p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene] and increased height and weight in adolescent boys. We examined a group with higher exposures to see whether similar associations would occur. Our study group was 304 males born in Philadelphia in the early 1960s who had participated in a previous study. Anthropometric and pubertal measures from one to six visits during their adolescent years were available, as were stored maternal serum samples from pregnancy. We measured p,p′-DDE, p,p′-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane], and o,p′-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane] in the maternal serum. Outcomes examined in the boys were height, ratio of sitting height to height, body mass index, triceps skinfold thickness, ratio of subscapular to the sum of triceps and subscapular skinfold thicknesses, skeletal age, serum testosterone, and serum dehydroepiandrosterone sulfate. No associations between prenatal exposure to any of the DDT compounds and any outcome measure were seen.

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mentioning

confidence: 99%

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

Gladen

Klebanoff

Hediger

et al. 2004

Environ Health Perspect

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“…The use of DDT in public health still remains controversial (Walker et al, 2003). However, it is currently used in a number of countries for vector control and is still one of the insecticides recommended by WHO for indoor residual spraying (Sadasivaiah et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

DDT and pyrethroid resistance status and laboratory evaluation of bio-efficacy of long lasting insecticide treated nets against Culex quinquefasciatus and Culex decens in Ghana

et al. 2015

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“…It was first synthesized by an Austrian chemist, Othmar Zeidler, in 1874 [1], but its insecticidal properties were not discovered until 1939, by Paul Muller, a Swiss entomologist, who won the Nobel Prize for this discovery [2]. Its first use as an insecticide was during World War II for the protection of the Allied forces from diseases such as typhus and malaria, which were spread by mosquitoes and lice to humans [2,3]. This breakthrough, in addition to its effectiveness and low price, led to its commercialization and use for agricultural purposes [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Its first use as an insecticide was during World War II for the protection of the Allied forces from diseases such as typhus and malaria, which were spread by mosquitoes and lice to humans [2,3]. This breakthrough, in addition to its effectiveness and low price, led to its commercialization and use for agricultural purposes [1,2]. One of its great successes was the elimination of malaria from Europe and the USA [1].…”

Section: Introductionmentioning

confidence: 99%

DDT and Metabolites

Mirmigkou

Boer

2015

The Handbook of Environmental Chemistry

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Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO). DDT is toxic to animals and humans. Its main characteristics are its persistence, lipophilicity, and bioaccumulative potential. DDT and its metabolites are normally determined in organisms, sediments, or soil by gas chromatography combined with either electron capture detection or, preferably, mass spectrometry. Many interlaboratory studies have been carried out on the analysis of DDT and its metabolites, and certified reference materials are now available. DDT and its metabolites have been found in air, water, sediment, and biota from all over the world. As a consequence of global fractionation and cold condensation, DDT and its metabolites accumulate in the Arctic. Since the reintroduction of DDT against malaria in Africa in 2005, monitoring of DDT compounds is again highly relevant to detect changes in environmental levels of DDT. Such monitoring is particularly needed in Africa. The first indications show an increase of DDT in humans and wildlife.

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Developing an international consensus on DDT: a balance of environmental protection and disease control

Cited by 21 publications

References 39 publications

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males

DDT and pyrethroid resistance status and laboratory evaluation of bio-efficacy of long lasting insecticide treated nets against Culex quinquefasciatus and Culex decens in Ghana

DDT and Metabolites

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