Developing an integrated microfluidic and miniaturized electrochemical biosensor for point of care determination of glucose in human plasma samples

Azimi, Shamim; Farahani, Ali; Docoslis, Aristides; Vahdatifar, Sahar

doi:10.1007/s00216-020-03108-3

Cited by 30 publications

(10 citation statements)

References 56 publications

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“…To complete the detection process on a microfluidic chip with several square centimeters, there is no doubt that the requirements for detection methods and devices are more stringent, at least to meet the characteristics of small size, high sensitivity, and rapid response speed ( Lin et al, 2006 ; Manz et al, 1995 ; Thorsen et al, 2002 ; Whitesides, 2006 ). The detection technologies of microfluidic chips include laser-induced fluorescence detection ( Ryu et al, 2011 ), UV absorption spectrophotometry detection ( Petersen et al, 2002 ; Verpoorte, 2002 ), chemiluminescence detection ( Wu et al, 2016 ), electrochemical detection ( Kim et al, 2005 ; Vandaveer et al, 2004 ; Verpoorte, 2002 ), mass spectrometry detection ( Thorslund et al, 2005 ), plasma emission spectroscopy detection ( Jenkins et al, 2005 ), thermal lens spectroscopy detection ( Franko et al, 2016 ), and biosensor detection ( Azimi et al, 2021 ). Optical detection and electrochemical detection are currently the most widely used detection methods.…”

Section: Applications Of Microfluidic Technology In Poctmentioning

confidence: 99%

Microfluidic technology and its application in the point-of-care testing field

Xie

Dai

Yang

2022

Biosensors and Bioelectronics: X

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Since the outbreak of the coronavirus disease 2019 (COVID-19), countries around the world have suffered heavy losses of life and property. The global pandemic poses a challenge to the global public health system, and public health organizations around the world are actively looking for ways to quickly and efficiently screen for viruses. Point-of-care testing (POCT), as a fast, portable, and instant detection method, is of great significance in infectious disease detection, disease screening, pre-disease prevention, postoperative treatment, and other fields. Microfluidic technology is a comprehensive technology that involves various interdisciplinary disciplines. It is also known as a lab-on-a-chip (LOC), and can concentrate biological and chemical experiments in traditional laboratories on a chip of several square centimeters with high integration. Therefore, microfluidic devices have become the primary implementation platform of POCT technology. POCT devices based on microfluidic technology combine the advantages of both POCT and microfluids, and are expected to shine in the biomedical field. This review introduces microfluidic technology and its applications in combination with other technologies.

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Section: Applications Of Microfluidic Technology In Poctmentioning

confidence: 99%

Microfluidic technology and its application in the point-of-care testing field

Xie

Dai

Yang

2022

Biosensors and Bioelectronics: X

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“…Microfluidics involves the manipulation of small amounts of fluids in channels with dimensions between tens and hundreds of micrometres [1]. The precise handling of fluids and cells, the portability of devices, and the reduction or elimination of cross-contamination are some of the advantages of such miniaturised systems, making them appealing for lab-on-chip applications [2][3][4]. Over the past decades, several microfluidic methods have been developed -such as dielectrophoresis [5], magnetophoresis [6], acoustophoresis [7], thermophoresis [8], pinched flow fractionation [9], deterministic lateral displacement [10] and inertial microfluidics [11] -and applied to cell separation [12,13], tissue engineering [14,15], drug and gene delivery systems [16,17] and clinical research [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Lattice-Boltzmann Modelling for Inertial Particle Microfluidics Applications — A Tutorial Review

Owen

Kechagidis

Bazaz

et al. 2023

Preprint

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Inertial particle microfluidics (IPMF) is an emerging technology for the manipulation and separation of microparticles and biological cells. Since the flow physics of IPMF is complex and experimental studies are often time-consuming or costly, computer simulations can offer complementary insights. In this tutorial review, we provide a guide for researchers who are exploring the potential of the lattice-Boltzmann (LB) method for simulating IPMF applications. We first review the existing literature to establish the state of the art of LB-based IPMF modelling. After summarising the physics of IPMF, we then present related methods used in LB models for IPMF and show several case studies of LB simulations for a range of IPMF scenarios. Finally, we conclude with an outlook and several proposed research directions.

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“…Projects based around the LMP91000 AFE (Texas Instruments), an IC used in a range of commercial portable potentiostats, 16 were reported in the literature. [18][19][20][21] The Analog Devices ADuCM355 SoC with integrated microcontroller, which equips commercial product (see e.g. ref.…”

Section: Introductionmentioning

confidence: 99%