Developing an antibacterial biomaterial

Guler, Selda; Ozseker, Emine Erdogan; Akkaya, Alper

doi:10.1016/j.eurpolymj.2016.09.031

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…The application of antimicrobial materials, which is based on the key materials antibacterial agents, has increased in various areas, particularly in medical devices, drugs, food packaging, textiles, health-care products, water purification systems, and so on. [1][2][3][4][5] In the last two decades, a great effort has been made to develop polymer materials with antimicrobial functions. [6][7][8][9][10][11] At present, the most commonly used antibacterial polymer materials are as follows.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and antibacterial activity of cationic nanopolystyrenes

Wen

Xiao

et al. 2019

J of Applied Polymer Sci

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Cationic nanopolystyrenes (CNPSs) were prepared by the polymerization of styrene with a cationic polymerizable emulsifier, N‐(2‐(methacryloyloxy)ethyl)‐N,N‐dimethyltetradecane‐1‐ammonium bromide (MDTB), in the presence of 2,2′‐azobis(2‐methylpropionamidine) dihydrochloride (APPH). The polymerization kinetics was investigated through monomer conversion versus polymerization time. 1H NMR spectra and FTIR spectra were used to confirm the structures of MDTB and nanopolymers. The particle size, ζ‐potential, molecular weight, and thermal stability were also investigated by Zetasizer, gel permeation chromatography, and thermogravimetric analysis, respectively. The antibacterial activities of the obtained products were evaluated by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Staphylococcus aureus ATCC 29913 (S. aureus, a Gram‐positive bacterium) and Escherichia coli ATCC 25922 (E. coli, a Gram‐negative bacterium). The results indicated that the polymerization has the characteristics of microemulsion polymerization, all nanopolystyrenes are cationic and can be stored in the form of a microemulsion in aqueous phase, CNPSs present stable chemical structure at 190 °C, and their MIC and MBC reach 0.0625 and 0.125 mg mL−1 for E. coli, 0.0325 and 0.0625 mg mL−1 for S. aureus, respectively. Therefore, CNPSs are a promising new type of polymer antimicrobial agent, which can be used in the development of antimicrobial polymer materials and their products. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48405.

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and antibacterial activity of cationic nanopolystyrenes

Wen

Xiao

et al. 2019

J of Applied Polymer Sci

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“…Therefore, the design of materials with the ability to significantly reduce the administration of antibiotics and avoid infections from highly antibiotic-resistant bacteria in the hospital environment are highly desirable. In this context, degradable polymers with tunable mechanical, biological and chemical properties and ease of fabrication can be attractive for aforementioned applications [7]. Through the combination of several biomaterials with inimitable properties, a tailor-made hybrid material can be designed without the use of any complicated fabrication approaches or chemistry.…”

Section: Introductionmentioning

confidence: 99%

Understanding the impact of crosslinked PCL/PEG/GelMA electrospun nanofibers on bactericidal activity

et al. 2018

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Herein, we report the design of electrospun ultrathin fibers based on the combination of three different polymers polycaprolactone (PCL), polyethylene glycol (PEG), and gelatin methacryloyl (GelMA), and their potential bactericidal activity against three different bacteria Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Methicillin-resistant Staphylococcus aureus (MRSA). We evaluated the morphology, chemical structure and wettability before and after UV photocrosslinking of the produced scaffolds. Results showed that the developed scaffolds presented hydrophilic properties after PEG and GelMA incorporation. Moreover, they were able to significantly reduce gram-positive, negative, and MRSA bacteria mainly after UV photocrosslinking (PCL:PEG:GelMa-UV). Furthermore, we performed a series of study for gaining a better mechanistic understanding of the scaffolds bactericidal activity through protein adsorption study and analysis of the reactive oxygen species (ROS) levels. Furthermore, the in vivo subcutaneous implantation performed in rats confirmed the biocompatibility of our designed scaffolds.

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“…Another essential requirement is vascularization or new blood vessel network creation, based on the principles of angiogenesis and vasculogenesis [ 145 ]. Alternatively, the escalating infectious diseases after operations are primary restrictions in biomedical applications [ 146 ]. Bacterial infections on the surface of the biomaterial biofilm have threatened to utilize biomaterials in the body [ 146 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Alternatively, the escalating infectious diseases after operations are primary restrictions in biomedical applications [ 146 ]. Bacterial infections on the surface of the biomaterial biofilm have threatened to utilize biomaterials in the body [ 146 ]. Regardless of the reliable host immune system, the implant surface might be quickly filled by bacteria, leading to infection persistence, implant failure, and even death of the patients.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

A Review on Antibacterial Biomaterials in Biomedical Applications: From Materials Perspective to Bioinks Design

et al. 2022

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In tissue engineering, three-dimensional (3D) printing is an emerging approach to producing functioning tissue constructs to repair wounds and repair or replace sick tissue/organs. It allows for precise control of materials and other components in the tissue constructs in an automated way, potentially permitting great throughput production. An ink made using one or multiple biomaterials can be 3D printed into tissue constructs by the printing process; though promising in tissue engineering, the printed constructs have also been reported to have the ability to lead to the emergence of unforeseen illnesses and failure due to biomaterial-related infections. Numerous approaches and/or strategies have been developed to combat biomaterial-related infections, and among them, natural biomaterials, surface treatment of biomaterials, and incorporating inorganic agents have been widely employed for the construct fabrication by 3D printing. Despite various attempts to synthesize and/or optimize the inks for 3D printing, the incidence of infection in the implanted tissue constructs remains one of the most significant issues. For the first time, here we present an overview of inks with antibacterial properties for 3D printing, focusing on the principles and strategies to accomplish biomaterials with anti-infective properties, and the synthesis of metallic ion-containing ink, chitosan-containing inks, and other antibacterial inks. Related discussions regarding the mechanics of biofilm formation and antibacterial performance are also presented, along with future perspectives of the importance of developing printable inks.

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Developing an antibacterial biomaterial

Cited by 12 publications

References 23 publications

Preparation, characterization, and antibacterial activity of cationic nanopolystyrenes

Preparation, characterization, and antibacterial activity of cationic nanopolystyrenes

Understanding the impact of crosslinked PCL/PEG/GelMA electrospun nanofibers on bactericidal activity

A Review on Antibacterial Biomaterials in Biomedical Applications: From Materials Perspective to Bioinks Design

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