Developing an accurate empirical correlation for predicting anti-cancer drugs’ dissolution in supercritical carbon dioxide

There are many different kinds of chemotherapy or chemo drugs are used for treating cancer. All of These medicine from chemical composition, how they are prescribed and given, how useful they are in treating certain types of cancer, and the side effects they might have. Nobody can deny that all medicines to treat cancer work in the different ways. The solubility of Azathioprine, as an immunosuppressive and anti-cancer drug, in supercritical carbon dioxide (SC-CO2) was measured for the first time. Under the applied conditions in terms of pressure (120–270 bar) and temperature (308–338 K), mole fractions were obtained in the range of 0.27 × 10−5 to 1.83 × 10−5. Three types of methods including (1) two equations of states (EoSs), namely Peng-Robinson (PR) and Soave–Redlich–Kwong (SRK) with vdW2 mixing rule (2) expanded liquid theory (3) nine semi-empirical density-based models were selected to correlate the solubility data of drug. Our developed correlation presents the absolute average relative deviation (AARD) of 9.54% for predicting 316 experimental measurements. After all we show that, the most accurate correlation in the literature presents the AARD = 14.90% over the same database. Furthermore, 56.2% accuracy improvement in the solubility prediction of the anti‑cancer drugs in supercritical CO2 is the primary outcome of the current study.

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“…Furthermore, it is found that less than 7.5% of the literature data are suspect information, and the remaining 92.5% are valid measurements. (4)…”

Section: Discussionmentioning

confidence: 99%

Predicting anti‑cancer drugs’ dissolution in supercritical carbon dioxide

et al. 2023

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“…The stratum corneum, composed of corneocytes and a lipid-rich matrix, serves as the skin’s principal barrier (chain ceramides, free fatty acids, and cholesterol). It blocks the skin’s ability to take hydrophilic or macromolecular drugs [ 35 ]. As the stratum corneum is impenetrable for most drugs, a biochemical strategy is needed to transport both hydrophilic and hydrophobic therapeutic molecules into the skin, and lipid-based nano-drug delivery devices are one such method.…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

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Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

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“…Moreover, they have great potential to be used in DDS via skin for transdermal drug delivery applications. In addition, hydrogels may be able to sustain the release of drugs when they are utilized in tissue engineering and cancer therapy [80]. This shows that hydrogels can be considered a perfect-matched option for use in various fields such as anticancer drugs, contact lenses, regenerative medicine, tissue engineering, barrier material to regulate adhesions, food packaging, and controlled DDS that derives from the high water content and hydrophilic nature of hydrogels.…”

Section: Biomedical Applications Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

et al. 2022

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Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.

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Developing an accurate empirical correlation for predicting anti-cancer drugs’ dissolution in supercritical carbon dioxide

Cited by 17 publications

References 73 publications

Predicting anti‑cancer drugs’ dissolution in supercritical carbon dioxide

Predicting anti‑cancer drugs’ dissolution in supercritical carbon dioxide

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems

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