Understanding the interactions of the social and biophysical drivers of land degradation is crucial for developing adaptive management actions for future sustainability. A research-praxis project, the ‘Tsitsa Project’ (TP), applies a social-ecological systems (SES) approach where researchers, natural resource managers, and residents collaborate to support sustainable livelihoods and improved natural resource management for the degraded Tsitsa River Catchment (TRC) in South Africa. A system diagramming approach was coupled with findings from interviews, workshops, literature, and two conceptual frameworks. Data inputs were qualitatively integrated to provide a systemic snapshot of how the context-specific social and biophysical drivers are interlinked and how they interact, revealing multiple processes that operate simultaneously to cause and exacerbate land degradation. Physical and climatic variables, changes in land use and cover, and overgrazing were identified as key factors leading to degradation. Additionally, poverty and disempowerment were also important. While little can be done to influence the physical aspects (steep topography and duplex soils) and climatic variables (extreme rainfall and drought), carefully planned changes in land use and management could produce dual-benefits for improving landscape conditions and sustainable livelihoods. This analysis will inform integrated planning processes to monitor, avoid, reduce and reverse land degradation.