“…These include the cytoskeleton (i.e., SPTN2, SPTB2, and FLNB), small GTPase signaling (i.e., DOCK1, DOCK9, and ARHG2), RNA processing (i.e., SF3B2 and SRRM1), and protein synthesis (i.e., IF4B, IF3A, and IF4G1). Interestingly, 12 known CASP3 substrates and 58 putative ones predicted by an in silico tool based on a position-specific scoring matrix approach ( Ayyash et al, 2012 ) were identified in the phosphoproteome of tBID ( Fig. 10 b and Table S1 ).…”