Developing a novel magnesium calcium phosphate/sodium alginate composite cement with high strength and proper self-setting time for bone repair

Abstract

In this work, novel magnesium calcium phosphate/sodium alginate composite cements were successfully fabricated with a proper setting time (5–24 min) and high compressive strength (91.1 MPa). The physicochemical and biological properties of the cement in vitro were fully characterized. The composite cements could gradually degrade in PBS as the soaking time increase, and the weight loss reached 20.74% by the end of 56th day. The cements could induce the deposition of Ca–P layer in SBF. Cell experiments proved that the extracts of the composite cements can effectively promote the proliferation and differentiation of the mouse bone marrow mesenchymal stem cells (MSCs). These preliminary results indicate that the magnesium calcium phosphate/sodium alginate composite cements could be promising as potential bone repair candidate materials.

Polyaspartic Acid-Stabilized CaCO3-Containing In Situ Hydrogel for Protection and Treatment of Gastric Ulcer

“…The manner of Ca 2+ incorporation is reported to affect the properties of the formed gels. 28 If calcium ions are added too quickly to SA solution, inhomogeneous gels are formed and the structure tends to lose continuity, forming gel fragments. Uniform gels can be obtained using calcium salts with slow and controlled dissolution.…”

Incorporation of clay minerals into magnesium phosphate bone cement for enhancing mechanical strength and bioactivity

“…Thereby, it is very necessary to introduce the retardants into MPCs system to adjust the self-setting speed. The common retardants added to control the reaction speed, includes inorganic substance (calcium dihydrogen phosphate [8], calcium sulfate [9]), organic small substance (citric acid [10]), natural macromolecules (carboxymethyl chitosan [11], sodium alginate [12]) and other bioactive substances. However, it is still difficult to realize a good balance between compressive strength and cytocompatibility during setting time.…”

Fabricating biodegradable calcium phosphate/calcium sulfate cement reinforced with cellulose:in vitroandin vivostudies

“…Several studies have been devoted to optimizing cement formulations in recent years. [43][44][45][46][47][48][49][50][51] However, these formulations still have not achieved better degradation and were not further investigated for inflammatory responses between tissue and cement.…”