2005
DOI: 10.1123/att.10.4.56
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Developing a Healthy Culture

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“…Tramadol hydrochloride 9 is traditionally prepared by treatment of 3-methoxyphenylmagnesium bromide 2e with 2-[(dimethylamino)methyl]cyclohexanone 10 in THF, followed by precipitation as the hydrochloride in different solvents. 6 We investigated this reaction both in 2-MeTHF and THF under similar reaction conditions. Compared with previous reported methodologies, the present protocol featured less solvent, a shorter reaction time and higher conversion (Table 3).…”
mentioning
confidence: 99%
“…Tramadol hydrochloride 9 is traditionally prepared by treatment of 3-methoxyphenylmagnesium bromide 2e with 2-[(dimethylamino)methyl]cyclohexanone 10 in THF, followed by precipitation as the hydrochloride in different solvents. 6 We investigated this reaction both in 2-MeTHF and THF under similar reaction conditions. Compared with previous reported methodologies, the present protocol featured less solvent, a shorter reaction time and higher conversion (Table 3).…”
mentioning
confidence: 99%