Developing a five-step training model for transperineal prostate biopsies in a naïve residents’ group: a prospective observational randomised study of two different techniques

Mantica, Guglielmo; Pacchetti, Andrea; Aimar, R.; Cerasuolo, Mattia; Dotta, Federico; Olivero, Alberto; Pini, Giovannalberto; Passaretti, Giovanni; Maffezzini, Massimo; Terrone, Carlo

doi:10.1007/s00345-018-2599-6

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Transperineal prostate biopsies were performed using either the “fan technique” (FT) or the Free Hand technique (FH). 22 …”

Section: Methodsmentioning

confidence: 99%

“…21 Transperineal prostate biopsies were performed using either the "fan technique" (FT) or the Free Hand technique (FH). 22 Moreover, we included MRI ultrasound fusion biopsies performed with a transrectal approach at all institutions. In these cases, combined targeted and systematic biopsies were performed according to the current EAU guidelines.…”

Section: Study Population and Study Designmentioning

confidence: 99%

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Correlation Between Long-Term Acetylsalicylic Acid Use and Prostate Cancer Screening with PSA. Should We Reduce the PSA Cut-off for Patients in Chronic Therapy? A Multicenter Study

Mantica¹,

Chierigo²,

Cassim³

et al. 2022

RRU

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Purpose To evaluate the prostate cancer (PCa) detection rate in men with chronic use of Aspirin and to compare it with the detection rate of non-users. Patients and Methods Prospectively maintained database regarding patients undergoing prostate biopsy over the last 10 years in five institutions. Patients were divided into two groups according to their exposure to Aspirin. We relied on multivariable linear and logistic regression models to test whether Aspirin administration was associated with lower PSA values at prostate biopsy, higher PCa diagnosis, and higher Gleason Grade Grouping (GGG) at biopsy. Results Were identified 1059 patients, of whom 803 (76%) did not take Aspirin vs 256 (24%) were taking it. In multivariable log-linear regression analysis, Aspirin administration was associated with lower PSA levels (OR 0.83, 95% CI 0.71–0.97, p = 0.01), after controlling for age, prostate volume, smoking history, associated inflammation at prostate biopsy, presence of PCa at biopsy, and GGG. In multivariable logistic regression analysis, Aspirin administration was not found to be a predictor of PCa at prostate biopsy (OR 1.40, 95% CI 0.82–2.40, p = 0.21) after controlling for age, PSA, smoking history, prostate volume, findings at digital rectal examination and the number of biopsy cores. In patients with PCa at prostate biopsy (n = 516), Aspirin administration was found to predict higher GGG (OR 2.24, 95% CI 1.01–4.87, p = 0.04). Conclusion Aspirin administration was found to be a predictor of more aggressive GGG. These findings suggest that a lower PSA threshold should be considered in patients taking Aspirin, as, despite low PSA levels, they might harbour aggressive PCa.

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“…Transperineal prostate biopsies were performed using either the “fan technique” (FT) or the Free Hand technique (FH). 22 …”

Section: Methodsmentioning

confidence: 99%

Section: Study Population and Study Designmentioning

confidence: 99%