Develop Tandem Tension Sensor to Gauge Integrin-Transmitted Molecular Forces
Gopal Niraula,
Arghajit Pyne,
Xuefeng Wang
Abstract:DNA-based tension sensors have innovated the imaging and calibration of mechanosensitive receptor-transmitted molecular forces, such as integrin tensions. However, these sensors mainly serve as binary reporters, only indicating if molecular forces exceed one predefined threshold. Here, we have developed tandem tension sensor (TTS), which comprises two consecutive force-sensing units, each with unique force detection thresholds and distinct fluorescence spectra, thereby enabling the quantification of molecular … Show more
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