Deutsch-Österreichische Empfehlungen zur HIV-Therapie in der Schwangerschaft und bei HIV-exponierten Neugeborenen – Update 2008

doi:10.1055/s-0028-1123974

Cited by 6 publications

(4 citation statements)

References 78 publications

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“…In our population, 26.9% are late preterm deliveries (34–36 + 6 weeks of gestation) and are mostly iatrogenic due to early caesarean section as in other studies and in the past [25]. The updated national German-Austrian Guidelines now delay caesarean section to term in women with suppressed VL [8]. The numbers of women with fully suppressed VL (VL < 50 copies/mL) ( P < 0.001) and CD4 cells ≥350 ( P > 0.20) prior to birth increased over the last years.…”

Section: Discussionmentioning

confidence: 85%

“…A change in treatment policies is evident over the 11 years of the study, reflected in the changes in delivery mode over time and the gestational age at delivery [8]. A high preterm delivery rate is confirmed by other groups [6].…”

Section: Discussionmentioning

confidence: 99%

“…Before that time, women were offered elective caesarean section at around 37 + 0 weeks of gestation [3, 8, 19]. With evidence for the safety of the vaginal birth with undetectable VL, the policy in the unit shifted towards planned vaginal birth, and if caesarean section was offered in these cases, the delivery was delayed until >37 weeks of gestation according to the German-Austrian Guidelines [3, 4, 8]. The following neonatal data were included: APGAR score, arterial cord pH (apH), cord base excess (BE) and neonatal weight (stratified according to 10th, 10–90th and >90th percentile).…”

Section: Methodsmentioning

confidence: 99%

“…The literature suggests that there is no increased rate of fetal malformations due to the HIV infection or HAART [6, 7]. A pregnant woman with HIV infection usually has intensified prenatal care including referral for prenatal ultrasound screening [8]. …”

Section: Introductionmentioning

confidence: 99%

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Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Reitter

Stücker

Buxmann

et al. 2013

Infectious Diseases in Obstetrics and Gynecology

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Objective. To assess the prevalence of prenatal screening and of adverse outcome in high-risk pregnancies due to maternal HIV infection. Study Design. The prevalence of prenatal screening in 330 pregnancies of HIV-positive women attending the department for prenatal screening and/or during labour between January 1, 2002 and December 31, 2012, was recorded. Screening results were compared with the postnatal outcome and maternal morbidity, and mother-to-child transmission (MTCT) was evaluated. Results. One hundred of 330 women (30.5%) had an early anomaly scan, 252 (74.5%) had a detailed scan at 20–22 weeks, 18 (5.5%) had a detailed scan prior to birth, and three (0.9%) had an amniocentesis. In seven cases (2.12%), a fetal anomaly was detected prenatally and confirmed postnatally, while in eight (2.42%) an anomaly was only detected postnatally, even though a prenatal scan was performed. There were no anomalies in the unscreened group. MTCT occurred in three cases (0.9%) and seven fetal and neonatal deaths (2.1%) were reported. Conclusion. The overall prevalence of prenatal ultrasound screening in our cohort is 74.5%, but often the opportunity for prenatal ultrasonography in the first trimester is missed. In general, the aim should be to offer prenatal ultrasonography in the first trimester in all pregnancies. This allows early reassurance or if fetal disease is suspected, further steps can be taken.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Reitter

Stücker

Buxmann

et al. 2013

Infectious Diseases in Obstetrics and Gynecology

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Prenatal ultrasound screening and pregnancy outcomes in HIV-positive women in Germany: results from a retrospective single-center study at the Charité-Universitätsmedizin Berlin

Hofacker,

Weichert,

Feiterna-Sperling

et al. 2023

Arch Gynecol Obstet

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Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study

Reitter

Buxmann

Haberl

et al. 2015

Med Microbiol Immunol

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Co-infection with CMV in HIV-positive pregnant women is associated with perinatal mother-to-child transmission (MTCT) of both viruses. This retrospective study reports on the incidence of maternal and neonatal CMV (presence of anti-CMV IgG and IgM, CMV DNA PCR and/or CMV virus isolation) in high-risk pregnancies due to maternal HIV infection, MTCT of HIV and/or CMV. One hundred and eleven maternal samples and 75 matched neonatal samples were available for HIV and subsequent CMV testing. In this cohort of HIV-positive pregnant women, 96 (86.5 %) serum samples were anti-CMV IgG positive. In nine (9.4 %) of these, anti-CMV IgM was detected, and in none of them a maternal primary CMV infection was suspected. Fifty-seven (51.8 %) maternal serum samples were tested retrospectively by CMV DNA PCR; one sample was positive (0.9 %). All matched neonates were tested for HIV by PCR in the first month of life; HIV transmission was detected in one case. In 74 (67.2 %) of neonates, CMV testing was performed. Sixty-six of these serum samples were tested retrospectively by CMV DNA PCR. Two newborns (2.7 %) showed laboratory markers for CMV infection (one by detection of CMV DNA in plasma, and one by isolation of CMV from a urine sample). In the follow-up, neither of these two showed clinical signs for active CMV disease. We discussed these findings in the light of the national official guidelines. All CMV transmissions occurred due to maternal reinfection or endogenous reactivation. This suggests the success of highly active antiretroviral therapy in preventing MTCT of HIV and CMV disease and highlights the importance of adequate care and follow-up.

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Deutsch-Österreichische Empfehlungen zur HIV-Therapie in der Schwangerschaft und bei HIV-exponierten Neugeborenen – Update 2008

Cited by 6 publications

References 78 publications

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Prenatal Ultrasound Screening for Fetal Anomalies and Outcomes in High-Risk Pregnancies due to Maternal HIV Infection: A Retrospective Study

Prenatal ultrasound screening and pregnancy outcomes in HIV-positive women in Germany: results from a retrospective single-center study at the Charité-Universitätsmedizin Berlin

Incidence of CMV co-infection in HIV-positive women and their neonates in a tertiary referral centre: a cohort study

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