To date, most of the analysis of neutron time-of-flight data from inertial confinement fusion experiments has focused on the relatively small range of energies corresponding to the primary neutrons from deuterium–deuterium and deuterium–tritium fusion and has, therefore, employed instrument response functions (IRFs) corresponding to monoenergetic 2.45-MeV or 14.03-MeV neutrons. For the analysis of time-of-flight signals corresponding to broader ranges of neutron energies, accurate treatment of the data requires the use of an energy-dependent IRF. This work describes interpolation of the IRF for neutrons of arbitrary energy, construction of an energy-dependent IRF, and application of this IRF in a forward fit via matrix multiplication. As an example of the application of this method, an analysis of synthetic data relevant to tritium–tritium fusion experiments at the Omega Laser Facility is discussed. This example is used to illustrate the differences between a forward fit that uses an energy-dependent IRF and a forward fit that uses a monoenergetic IRF. Use of the energy-dependent IRF is shown to result in accurate inference of the fit parameters of interest.