Deuterium Oxide Enhances Expression of the ada, alkA, and luxA Genes of Escherichia coli Induced by Methyl Methanesulfonate

Свиридова, Д. А.; Smirnova, S. V.; Абилев, С. К.

doi:10.1134/s1022795422040135

Cited by 1 publication

(1 citation statement)

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“…The influence of the isotopic 2 H-effect on nucleic acids structure and their functions is being actively studied, and it is relevant for various fields of science [ 19 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. So, our data allows to understand the mechanism of the possible changes in the OS occurrence frequency in IFNA17 by the single 2 H/ 1 H-replacement under specific energy range more precisely.…”

Section: Discussionmentioning

confidence: 99%

Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

Басов

Drobotenko

Svidlov

et al. 2022

IJMS

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The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single 2H/1H substitutions in certain nitrogenous bases can be a mechanism for maintaining the vital activity of IFNA17 under critical conditions. In general, the developed method of the mathematical modeling provide unprecedented insight into the DNA behavior under the highest critical energy range, which greatly expands scientific understanding of nucleobases interaction.

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