Deuterated Drugs and Biomarkers in the COVID-19 Pandemic

Vuuren, Ross D. Jansen-van; Jedlovčnik, Luka; Košmrlj, Janez; Massey, Thomas E.; Derdau, Volker

doi:10.1021/acsomega.2c04160

Cited by 18 publications

(19 citation statements)

References 105 publications

(204 reference statements)

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“…Moreover, these individuals are considerably more susceptible to severe COVID-19-related fatalities. [39] As such, the clinical safety and efficacy of drugs in this specific patient population should be given primary consideration in the development of oral antiviral drugs.…”

Section: Discussionmentioning

confidence: 99%

The safety and efficacy of oral antiviral drug VV116 for treatment of COVID-19: A systematic review

Xiao

Huang

et al. 2023

Medicine

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Background: Recent trials have highlighted the potential of oral antiviral VV116 in the treatment of patients with mild COVID-19. However, no comprehensive studies have assessed the safety and efficacy of VV116. Therefore, we conducted a systematic review to assess the safety and efficacy of VV116. Methods: A comprehensive search was conducted on PubMed, Scopus, and Google Scholar websites, with a cutoff date of March 23, to identify pertinent studies. Results: The results from the 3 included studies indicated that no serious adverse events were reported in the VV116 experimental groups, which exhibited a 2.57-day faster time to viral shedding than the control group and demonstrated non-inferiority to the nirmatrelvir-ritonavir control group in alleviating major symptoms. Discussion: Collectively, available studies suggest a reliable safety and efficacy profile for VV116. However, the limited number of trials was insufficient for meta-analysis, and the included population consisted of younger individuals with mild and moderate symptoms, not encompassing the elderly who are severely affected by COVID-19. We hope that more studies will be conducted in the future to ensure that VV116 has a more reliable safety and efficacy profile in the clinical setting, especially in severe or critical patients.

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Section: Discussionmentioning

confidence: 99%

The safety and efficacy of oral antiviral drug VV116 for treatment of COVID-19: A systematic review

Xiao

Huang

et al. 2023

Medicine

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“…1a). In addition, deuterium-labeled compounds have been employed either as potential therapeutic agents or as internal MS standards for studying the pharmacological properties of new drugs by quantifying the parent compounds and metabolites, especially during the coronavirus disease 2019 (COVID-19) pandemic 9 . Notably, several D-labeled compounds show potential therapeutic for COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic Reductive Deuteration of (Hetero)Arenes

Lei

Deng

et al. 2023

Preprint

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The incorporation of deuterium to organic molecules have widespread applications in medicinal chemistry and material science1,2. For example, deuterated drugs e.g. Austedo3, Donafenib4 and Sotyktu5 have been approved, recently. Because of all these applications, developing methodologies for the synthesis of deuterated compounds with high deuterium ratios is highly desirable6. However, reductive deuteration of aromatic hydrocarbons, which are ubiquitous skeletal features in inert chemical feedstocks, to saturated cyclic compounds, including heterocyclic skeletons has been rarely achieved. So far, only few methods have been reported for direct reductive deuteration using stoichiometric strong reducing agents or D2. Here, we describe a scalable and general electrocatalytic method for the reductive deuteration and deuterodefluorination of (hetero)arenes using a prepared nitrogen doped electrode and D2O, giving perdeuterated and saturated deuterocarbons. This protocol has been successfully applied to the high incorporation of deuterium in 13 drugs.

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“…Deuterium (D, 2 H) is a stable and non-radioactive isotope of hydrogen, and deuterium-incorporating (deuterated) compounds are widely used in various scientific applications. [1][2][3] The phenomenon in which the carbondeuterium (C-D) bond is stronger than the carbon-hydrogen (C-H) bond is known as the kinetic isotope effect (KIE). The differential strength between the C-D and C-H bonds has led to the development of deuterated drugs.…”

Section: Introductionmentioning

confidence: 99%