Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression
Zhenhua Xu,
Qiaozhen Qin,
Yan Wang
et al.
Abstract:Neural stem cells (NSCs) are critical for brain development and maintenance of neurogenesis. However, the molecular mechanisms that regulate NSC proliferation and differentiation remain unclear. Mysm1 is a deubiquitinase and is essential for the self-renewal and differentiation of several stem cells. It is unknown whether Mysm1 plays an important role in NSCs. Here, we found that Mysm1 was expressed in NSCs and its expression was increased with age in mice. Mice with Mysm1 knockdown by crossing Mysm1 floxed mi… Show more
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