Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-κB signaling to protect mice from sepsis-induced acute kidney injury

Luo, Shu; Gong, Junzuo; Zhao, Shiqiao; Li, M.; Li, Ruixiu

doi:10.1016/j.cbi.2023.110621

Cited by 2 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E2F1 [265], BMI1 [260], VCAM1 [321], AGTR1 [64], hsa-mir-638 [790], hsa-mir-221 [791], FOXC1 [792], YY1 [793], STAT3 [794] and BRCA1 [795] provided a clear picture of the prognosis of patients with hypertension. E2F1 [329], BMI1 [327], VCAM1 [376], USF2 [796], YY1 [797], STAT3 [798] and BRCA1 [799] have always been found in AKI. Identified E2F1 [382], BMI1 [378], VCAM1 [421], AGTR1 [87], MEF2A [800] and STAT3 [798] as a biomarkers for chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

“…E2F1 [433], VCAM1 [485], AGTR1 [71], hsa-mir-221 [801], MEF2A [802] and YY1 [803] are associated with developing liver diseases. E2F1 [496], AGTR1 [74], VCAM1 [533], hsa-mir-7847-3p [804], FOXC1 [805], USF2 [796], YY1 [806], STAT3 [807] and BRCA1 [799] have been observed in sepsis patients. Studies have shown that E2F1 [669], VCAM1 [715], AGTR1 [83], hsa-mir-221 [780], YY1 [808], STAT3 [809], PDX1 [810] and BRCA1 [811] are associated with obesity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a type of renal disease occurs frequently in hospitalized patients, which may cause abnormal renal function and structure with increase in serum creatinine level with or without reduced urine output. With the incidence of AKI is increasing. However, the molecular mechanisms of AKI have not been elucidated. It is significant to further explore the molecular mechanisms of AKI. We downloaded the GSE139061 next generation sequencing (NGS) dataset from the Gene Expression Omnibus (GEO) database. Limma R bioconductor package was used to screen the differentially expressed genes (DEGs). Then, the enrichment analysis of DEGs in Gene Ontology (GO) function and REACTOME pathways was analyzed by g:Profiler. Next, the protein-protein interaction (PPI) network and modules was constructed and analyzed, and the hub genes were identified. Next, the miRNA-hub gene regulatory network and TF-hub gene regulatory network were built. We also validated the identified hub genes via receiver operating characteristic (ROC) curve analysis. Overall, 956 DEGs were identified, including 478 up regulated and 478 down regulated genes. The enrichment functions and pathways of DEGs involve primary metabolic process, small molecule metabolic process, striated muscle contraction and metabolism. Topological analysis of the PPI network and module revealed that hub genes, including PPP1CC, RPS2, MDFI, BMI1, RPL23A, VCAM1, ALB, SNCA, DPP4 and RPL26L1, might be involved in the development of AKI. miRNA-hub gene and TF-hub gene regulatory networks revealed that miRNAs and TFs including hsa-mir-510-3p, hsa-mir-6086 and mir-146a-5p, MAX and PAX2, might be involved in the development of AKI. Various known and newtherapeutic targets were obtained via network analysis. The results of the current investigation might be beneficial for the diagnosis and treatment of AKI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…As E3 ubiquitin ligases, WWP2 and HRD1 have been proven to inhibit the apoptosis of RTECs caused by renal injury [ 44 , 45 ]. BAP1, acting as deubiquitinase, enhances the stability of BRCA1 protein through deubiquitination, suppresses NF-κB signaling, and ultimately mitigates LPS-induced RTEC injury and apoptosis [ 18 ]. Liu et al.…”

Section: Discussionmentioning

confidence: 99%

“…Deubiquitinating enzymes (DUBs) remove ubiquitin modification and enhance protein stability [ 17 ]. A growing number of DUBs, such as BAP1, USP36, and USP7, has been implicated in manipulating pathological changes, inflammatory responses, apoptosis, and oxidative stress in renal tissue [ 18–20 ]. The termination of the inflammatory response is facilitated by the intracellular translocation of TLR4 followed by its degradation through the ubiquitin-proteasome system pathway [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway

Gong,

Xiong,

Lei

et al. 2024

Renal Failure

View full text Add to dashboard Cite

Deubiquitinase BAP1 regulates stability of BRCA1 protein and inactivates the NF-κB signaling to protect mice from sepsis-induced acute kidney injury

Cited by 2 publications

References 42 publications

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway

Contact Info

Product

Resources

About