Detritussynovialitis und seltene Skeletterkrankungen

Abstract

Detritic synovitis represents a common finding in routine orthopedic pathology. Microscopically, the synovium displays cartilaginous and bony fragments in the synoviocyte layer or within the subsynovial soft tissues associated with resorptive changes. In the vast majority of cases, detritic synovitis is associated with conditions leading to the destruction of articular cartilage and subchondral bone, such as severe osteoarthritis, collapsed avascular necrosis, diabetes mellitus, Charcot arthropathy or non-union fractures. The objective of this article is to review the literature regarding the microscopic findings in ochronosis, rapidly destructive hip disease and apatite crystal depositions that can enable a confident diagnosis or a limited differential diagnosis of detritic synovitis.

Pyroptosis-related crosstalk in osteoarthritis: Macrophages, fibroblast-like synoviocytes and chondrocytes

“…During the process of ‘mechanical crosstalk’, CC pyroptosis disrupts the balance between extracellular matrix (ECM) synthesis and catabolism, leading to cartilage breakdown. The shedding of cartilage fragments into synovial fluid induces secondary damage to the synovium [ [71] , [72] , [73] ]. On the other hand, pyroptosis occurring in FLS and MC can accelerate synovial fibrosis [ 13 , 70 ].…”

Orthopedic and histopathological study on “detritic synovitis” in cases of primary and revision total hip arthroplasty

“…Detritic synovitis (DS) is recognized in resected synovial tissue by primary total hip arthroplasty (PTHA), and reveals fragments of hyaline cartilage and bone on the synovial lining in cases such as osteoarthritis (OA), rheumatoid arthritis and so forth, related to destruction of bone and joint structure . DS is primarily manifested on the synovial lining and just below the synovial cell layer, but the bone chip is clinically not problematic in and of itself.…”