Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration

Anand, Surendra Kumar; Ahmad, Mir Hilal; Sahu, Manas Ranjan; Subba, Rhea; Mondal, Amal Chandra

doi:10.1007/s10571-022-01308-2

Cited by 15 publications

(9 citation statements)

References 185 publications

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“…Furthermore, alcohol use is associated with compromised white matter ( Yalcin et al, 2017 ) and brain atrophy in MRI studies ( Mukamal et al, 2001 ). Alcohol consumption can also, via both direct and indirect pathways, trigger pro-inflammatory effects within the brain - leading to neurodegeneration and decreased adult neurogenesis ( Anand et al, 2023 ). It can also compromise the integrity of the blood brain barrier by increasing oxidative stress in endothelial cells ( Haorah et al, 2005 ) complementing work in other in vitro studies ( Carrino et al, 2021 ).…”

Section: Adultsmentioning

confidence: 99%

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Seemiller,

Flores-Cuadra,

Griffith

et al. 2024

Neurobiology of Stress

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Section: Adultsmentioning

confidence: 99%

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Seemiller,

Flores-Cuadra,

Griffith

et al. 2024

Neurobiology of Stress

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“…A large-scale study suggested an association between increased risk of LHON triggering and alcohol only in patients with a heavy alcohol intake [ 16 ]. Alcohol neuropathogenicity has been known for many years [ 70 ], and the association of either acute or chronic ethanol exposure with caspase 3 activation, neuronal cell death, and neurodegeneration has been demonstrated in rodent models [ 71 ]. Mitochondria are the primary targets of chronic alcohol intake due to direct or indirect inhibition of complexes I and III and increased production of ROS and reactive nitrogen species (RNS) resulting from ethanol metabolism [ 72 ].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy

Layrolle,

Orssaud,

Leleu

et al. 2024

Biomedicines

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Optic neuropathies are characterized by the degeneration of the optic nerves and represent a considerable individual and societal burden. Notably, Leber’s hereditary optic neuropathy (LHON) is a devastating vision disease caused by mitochondrial gene mutations that hinder oxidative phosphorylation and increase oxidative stress, leading to the loss of retinal ganglion neurons and axons. Loss of vision is rapid and severe, predominantly in young adults. Penetrance is incomplete, and the time of onset is unpredictable. Recent findings revealed that the incidence of genetic LHON susceptibility is around 1 in 1000, much higher than believed till now. Environmental factors are critical in LHON triggering or severity. Families at risk have a very strong demand for how to prevent the onset or limit the severity of the disease. Here, we review recent knowledge of the extrinsic determinants of LHON expression, including lifestyle, dietary supplements, common chemicals, and drugs.

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“…Many drugs abused have a high inflammatory potential and the ability to alter the functioning of the immune system [47][48][49][50]. The inflammatory potential of alcohol at the hepatic level is well known.…”

Section: New Approaches To the Study Of The Addictive Process: Neuroi...mentioning

confidence: 99%

Neurobiological Theories of Addiction: A Comprehensive Review

Ferrer-Pérez,

Montagud-Romero,

Blanco-Gandía

2024

Psychoactives

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It is essential to develop theories and models that enable us to understand addiction’s genesis and maintenance, providing a theoretical and empirical framework for designing more effective interventions. Numerous clinical and preclinical research studies have investigated the various brain and physiological mechanisms involved in addictive behavior. Some researchers have gone a step further, developing what we may refer to as “neurobiological theories of addiction”, which are scientific models that can explain and predict different addiction phenomena. Many of these neurobiological theories are not mutually exclusive but rather extensions and refinements of earlier theories. They all share a similar definition of addiction as a chronic disease characterized by a loss of control over substance consumption, with the brain being identified as the principal organ involved. Most propose a multifactorial causation in which both biological and environmental factors interact, accentuating or causing neurobiological dysfunction in structures and brain circuits involved in behavior and motivation. This review delves into primary neurobiological theories of addiction, commencing with the opponent-process theory—one of the earliest comprehensive explanations of the addictive process. Subsequently, we explore more contemporary formulations connecting behavioral alterations in the addictive process to changes and disruptions in various brain systems.

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Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration

Cited by 15 publications

References 185 publications

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy

Neurobiological Theories of Addiction: A Comprehensive Review

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