Detrimental effects of 6 months exposure to very low doses of a mixture of six pesticides associated with chronic vitamin deficiency on rats

Tsatsakis, Aristidis; Тышко, Н В; Γούμενου, Μαρίνα; Shestakova, S.I.; Sadykova, E.O.; Zhminchenko, V. M.; Zlatian, Ovidiu; Calina, Daniela; Pashorina, V A; Nikitin, N.S.; Trebukh, M.D.; Loginova, Maria S; Трушина, Э Н; Мустафина, О К; Avrenyeva, Ludmila I.; Guseva, G V; Трусов, Н В; Кравченко, Л В; Hernández, Antonio F.; Docea, Anca Oana

doi:10.1016/j.fct.2021.112188

Cited by 9 publications

(3 citation statements)

References 64 publications

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“…Another example of relevant professionals are those working on the European Union risk assessment report, which is prepared by EU members in the Most real-world exposures to pollution involve multiple pollutants, and numerous chemicals co-occur in the environment, forming spatiotemporally diverse chemical mixtures to which living organisms are exposed. As a result of toxicodynamic interactions among chemicals J o u r n a l P r e -p r o o f comprising a mixture, the toxicological/effect outcome can change in terms of direction and magnitude (Tsatsakis et al, 2018(Tsatsakis et al, , 2021. In particular, the effect can be additive, positive synergistic, negative synergistic, positive antagonistic, and negative antagonistic (Fong et al, 2021).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

US EPA: Is there room to open a new window for evaluating potential sub-threshold effects and ecological risks?

Agathokleous

Barceló

Calabrese

2021

Environmental Pollution

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

US EPA: Is there room to open a new window for evaluating potential sub-threshold effects and ecological risks?

Agathokleous

Barceló

Calabrese

2021

Environmental Pollution

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“…To date, the toxicological evaluation of chemicals has focused on testing high-dose single chemicals in experimental animals to determine the safety margins and target organ(s) [ 24 , 25 ]. Unfortunately, this approach does not reflect the real-life exposure scenario in which individuals are exposed to multiple stressors at low doses at the same time [ 26 ]. In this study, we aimed to investigate the positive effects of probiotic S. boulardii on the male reproductive system under low dose neonicotinoid pesticides exposure conditions.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Sevim

Akpınar

Aksu

et al. 2023

Toxics

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The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.

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“…Due to its essential role in the visual system, acute vitamin A deprivation impairs photoreceptor function and causes night blindness (poor vision under dim light conditions), while chronic deprivation results in retinal dystrophies and photoreceptor cell death (Dewett et al, 2021;Medhat and Aljanaby, 2022). Tsatsakis et al ( 2021) study the effects of vitamin A on physiological parameters in rats, after 6 months, ten rats from each group were sacrificed and a complete evaluation of blood and urine biochemistry, biomarkersof oxidative stress , xenobiotic detoxification enzymes and lysosomal enzymes and organ histopathology was performed.…”

Section: Introductionmentioning

confidence: 99%

Histopathological effects of retinol on blastocyst implantation in pregnant rats

Ali

Abood

2022

ijhs

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Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, fifteen female Albino Rats are used. The present study has been intended to show the histolopathologiacl effects of retinol on blastocyst implantation in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given orally injection of physiological normal saline and the second and third group are given orally injection of retinol doses ten, twenty μcg/kg/day respectively for seven days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 7 th (dpc) to study the implantation of embryos in decidual tissues. Retinol doses ten, twenty μcg/kg/day caused macroscopic malformations in embryos of female rats compare to control group. The histopathlogical study of female rats embryos treated with ten, twenty μcg/kg/day of retinol have shown deformations of decidual tissues zonation.In conclusion; retinol caused malformations of embryos in 7 th (dpc) and histopathlogical effects in decidual tissue zonations of blastocyst.

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Detrimental effects of 6 months exposure to very low doses of a mixture of six pesticides associated with chronic vitamin deficiency on rats

Cited by 9 publications

References 64 publications

US EPA: Is there room to open a new window for evaluating potential sub-threshold effects and ecological risks?

US EPA: Is there room to open a new window for evaluating potential sub-threshold effects and ecological risks?

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Histopathological effects of retinol on blastocyst implantation in pregnant rats

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