Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock

Lin, Yu‐Ju; Tsai, Ching‐Chou; Huang, Laura; Sheen, Jiunn‐Ming; Tiao, Mao‐Meng; Yu, Hong‐Ren; Chen, Chih‐Cheng; Tain, You‐Lin

doi:10.1007/s10815-017-0915-5

Cited by 16 publications

(7 citation statements)

References 48 publications

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“…Different types of maternal nutritional status have been identified to program adult diseases [2]. And ample evidences demonstrated that maternal exposure to HFD during gestation and lactation has harmful effects on the offspring [20, 21]. In the present study, we focused on the influence of maternal exposure to HFD during gestation only to mimic the excessive gestational weight gain and investigated reproductive potential of the female offspring at PND4 and PND30.…”

Section: Discussionmentioning

confidence: 99%

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Zhou

Lin

et al. 2019

Reprod Biol Endocrinol

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BackgroundExcessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem. Accumulating evidence indicates that the ovary kisspeptin/GPR54 system directly participates in a series of physiological activities. We used a model of high-fat diet (HFD) during gestational to investigate offspring’s ovarian function and whether kisspeptin/GPR54 system is involved.MethodsAfter introducing the male and confirmation of mating by checking a vaginal sperm plug, female rats were randomized into two groups: control diet called NCD group and high-fat diet called HFD group. After birth, all rats were changed into a control diet and litter size was adjusted to 12 pups per litter. Ovaries were collected for assessment at postnatal day (PND) 4 and PND 30. The timing of vaginal opening was recorded, and the estrous cyclicity was monitored for 2 consecutive weeks immediately. Primary granulosa cells and ovaries which were taken from PND 4 were collected for determination of the direct effect of kisspeptin-10 (kp-10) in vitro.ResultsNeonatal rats exposed to HFD during gestation had a lower number of secondary follicles in the ovary. The expression of follicle-stimulating hormone receptor (FSHR) and kisspeptin was not altered. At prepuberty, the number of antral follicles and preovulatory follicles was elevated with decreased type III follicles in the HFD group. While the expression of ovulation-related genes was decreased, the expression levels of follicular growth-related genes and steroidogenesis synthesis related genes were elevated. A significant increase in kiss1 mRNA and kisspeptin protein was detected without changes in kiss1r mRNA and GPR54. Maternal high-fat diet during gestation resulted in a significant advanced puberty onset and an irregular estrous cycle in offspring rats. In addition, the administration of kp-10 produced an increase in viability of primary granulosa cells and enlarged the size of oocytes.ConclusionsHFD exposure during maternal gestation had a long-term effect on reproductive function in the offspring and the increased ovarian kisspeptin/GPR54 system might be involved.Electronic supplementary materialThe online version of this article (10.1186/s12958-019-0457-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Zhou

Lin

et al. 2019

Reprod Biol Endocrinol

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“…Studies in germ‐free mice will be instrumental in determining whether gut microbes are necessary or sufficient for the development of the PCOS. Second, both constant light exposure and an HFD have been shown to disrupt the circadian clock (9,10), but influence of constant light plus an HFD on rhythmic expression of clock genes in ovaries has never been reported, to our knowledge. Here, we only detected ovary expression of clock genes at the time of sacrifice.…”

mentioning

confidence: 89%

Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats

Yue

Lin

et al. 2022

Obesity

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Objective This study investigated the effects of constant light exposure on polycystic ovary syndrome (PCOS)‐like endocrine and metabolic changes in high‐fat diet (HFD)‐fed rats and to elucidate the related microbiotic mechanisms. Methods A total of 32 female Sprague‐Dawley rats were divided into four groups (n = 8 each): rats on a normal chow diet with standard light‐dark cycle, rats on a normal chow diet with constant light exposure, rats on an HFD with standard light‐dark cycle, and rats on an HFD with constant light exposure. After 16 weeks of treatment, changes in anthropometric parameters, estrous cycle, hormone profiles, ovarian pathology, and gut microbiota and short‐/medium‐chain fatty acids in colon contents were assessed. Results Constant light exposure aggravated PCOS‐like phenotypes in HFD‐fed rats, such as hyperandrogenism, disrupted estrous cycle, and polycystic ovaries. Additionally, constant light exposure and an HFD synergized to decrease α‐diversity of gut microbiota, create a reduced abundance of Ruminococcus genus, and create an increased abundance of Firmicutes and the Firmicutes/Bacteroidetes ratio. In HFD‐fed rats, the group with constant light exposure had an increase in propionate acid and a decrease in total medium‐chain fatty acids in colon contents compared with the standard light‐dark cycle group. Conclusions Constant light exposure causes gut dysbiosis, alters production of short‐ and medium‐chain fatty acids, and aggravates PCOS‐like traits in HFD‐fed rats.

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“…It has been demonstrated that high fat and sugar intake induces alterations in circadian clock function, which seems to be a factor in female reproductive timing, since such changes may harm synchronization between circadian rhythmicity and central or peripheral components. Recently, several studies have shown that high caloric intake leads to premature aging, altered sleep, and disruption in circadian rhythmicity [141][142][143][144]. Highlighting their significance, high-fat diet intake affects the ovarian circadian clock [145].…”

Section: High Fat Diet and Time-restricted Feeding Regulationmentioning

confidence: 99%

“…Highlighting their significance, high-fat diet intake affects the ovarian circadian clock [145]. Circadian core gene expression within ovarian cells revealed changes as a result of maternal and post-weaning high-fat diets [142,145]. Time-restricted feeding (TRF) has been known to prevent body weight gain associated with HFD feeding ad libitum in all genotypes without reducing food intake or increasing activity [146][147][148].…”

Section: High Fat Diet and Time-restricted Feeding Regulationmentioning

confidence: 99%

Circadian Clock, Time-Restricted Feeding and Reproduction

Pan

Taylor

Cohen

et al. 2020

IJMS

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The goal of this review was to seek a better understanding of the function and differential expression of circadian clock genes during the reproductive process. Through a discussion of how the circadian clock is involved in these steps, the identification of new clinical targets for sleep disorder-related diseases, such as reproductive failure, will be elucidated. Here, we focus on recent research findings regarding circadian clock regulation within the reproductive system, shedding new light on circadian rhythm-related problems in women. Discussions on the roles that circadian clock plays in these reproductive processes will help identify new clinical targets for such sleep disorder-related diseases.

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Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock

Cited by 16 publications

References 48 publications

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats

Circadian Clock, Time-Restricted Feeding and Reproduction

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