Detrended fluctuation analysis of compound action potentials re-corded in the cutaneous nerves of diabetic rats

Quiróz-González, Salvador; Rodríguez-Torres, Erika Elizabeth; Segura‐Alegría, Bertha; Pereira-Venegas, Javier; López-Gómez, Rosa Estela; Jiménez‐Estrada, Ismael

doi:10.1016/j.chaos.2015.12.011

Cited by 2 publications

(1 citation statement)

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“…Our results coincide with a large body of work showing that early negative (complete maternal deprivation, early weaning or undernourishment), or positive (tactile and social stimulation) experiences modify myelination and the electrophysiological function of the CNS (Chatterjee et al, ; Kikusui et al, ; Ono et al, ; Horiquini‐Barbosa and Lachat, ; Antoniazzi et al, ) and the PNS (Segura et al, ; Segura et al, ; Quiroz‐González et al, ). Moreover, our results allow us to propose a discrete window of developmental time (PNDs 7–14), during which tactile stimulation normally exerts positive effects on myelination (Kikusui et al, ; Ono et al, ).…”

Section: Discussionsupporting

confidence: 88%

Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation

Zempoalteca

Porras²,

Moreno-Pérez

et al. 2017

Developmental Neurobiology

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Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR-Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR-Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR-Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7-14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351-362, 2018.

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