Abstract:The venom from the snake Crotalus durissus terrificus was detoxified by stepwise incorporation of stable cationic iodine. The venoid, in a dosage equivalent to 100 LD50 of the lethal venom, was injected in mice without lethal exits. The native venom (NAT), or its toxoided (TXD) derivative were incubated in presence or absence of mitogens, with human mononuclear (MN), B and T cells, with a pulse of [3H]Thymidine. No synergistic or antagonistic effects were observed in the combined activity of the mitogens and N… Show more
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