Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

Gao, Xiaojuan; Mu, Peiqiang; Wen, Jikai; Sun, Yu; Chen, Qingmei; Deng, Yiqun

doi:10.1016/j.fct.2017.12.066

Cited by 72 publications

(54 citation statements)

References 58 publications

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“…De-epoxidation is one of the most important processes associated with DON detoxification. Previously, we isolated a bacterium, DII-9, which was effective for DON de-epoxidation [33]. Efforts to screen enzymes responsible for DON de-epoxidation in DII-9 have ended in failure.…”

Section: Discussionmentioning

confidence: 99%

“…Next, metabolic activity of D-G6 was compared to that of Raoultibacter sp. DII-9 (DII-9) [33]. Under low DON concentrations, the efficacies of D-G6 and DII-9 were comparable, but DII-9 was slightly more efficient than D-G6 when DON concentration was increased ( Table 1).…”

Section: The Metabolic Characteristics Of D-g6mentioning

confidence: 99%

“…DII-9 (now revised as Raoultibacter sp. DII-9 based on the latest species classification) from chicken intestine [33] have been identified. However, no genes responsible for de-epoxidation of DON have been identified so far.…”

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confidence: 99%

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Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

Gao

Zhu

et al. 2020

Toxins

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Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on humans and animals. Much effort has been made to control DON in the past, and bio-transformation has emerged as the most promising method. However, useful and effective application of bacterial bio-transformation for the purpose of inhibiting DON remains urgently needed. The current study isolated a novel DON detoxifying bacterium, Slackia sp. D-G6 (D-G6), from chicken intestines. D-G6 is a Gram-positive, non-sporulating bacterium, which ranges in size from 0.2–0.4 μm × 0.6–1.0 μm. D-G6 de-epoxidizes DON into a non-toxic form called DOM-1. Optimum conditions required for degradation of DON are 37–47 °C and a pH of 6–10 in WCA medium containing 50% chicken intestinal extract. Besides DON detoxification, D-G6 also produces equol (EQL) from daidzein (DZN), which shows high estrogenic activity, and prevents estrogen-dependent and age-related diseases effectively. Furthermore, the genome of D-G6 was sequenced and characterized. Thirteen genes that show potential for DON de-epoxidation were identified via comparative genomics. In conclusion, a novel bacterium that exhibits the dual function of detoxifying DON and producing the beneficial natural estrogen analogue, EQL, was identified.

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Section: Discussionmentioning

confidence: 99%

Section: The Metabolic Characteristics Of D-g6mentioning

confidence: 99%

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Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

Gao

Zhu

et al. 2020

Toxins

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“…Eggerthella sp. DII‐9, a novel deepoxidation bacterium from chicken intestines, was reported to have effectively transformed DON into DOM‐1 (Gao et al., 2018). Intestinal microorganisms from bovine rumen fluid, dairy cattle, pigs, rats, sheep, and fish digesta were able to convert DON (Côté, Dahlem, Yoshizawa, Swanson, & Buck, 1986; Cote, Nicoletti, Swanson, & Buck, 1986; Guan et al., 2009; King et al., 1984; Kollarczik et al., 1994; Westlake, Mackie, & Dutton, 1989; Yoshizawa, Takeda, & Ohi, 1983).…”

Section: Degradation Of Don By Microorganismsmentioning

confidence: 99%

“…The use of whole bacterial cells in industrial applications may be the most feasible means of remission (Bullerman, Giesova, Hassan, Deibert, & Ryu, 2006; Hassan & Bullerman, 2013). Some microorganisms and enzymes have been applied for patent and regarded as potential feed additives (Gao et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Deoxynivalenol: Masked forms, fate during food processing, and potential biological remedies

Guo

Wang

et al. 2020

Comp Rev Food Sci Food Safe

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Deoxynivalenol (DON) has drawn global attention because of its prevalence and significant effects on human or animal health. Biological remedies for DON have been developed from preharvest to postharvest. Applying microbes, including bacteria, fungi (yeast and molds), and enzymes, results in inhibited synthesis, structural destruction, or adsorption of DON. DON can be degraded into masked forms by phase I metabolism or phase II metabolism. During food processing, DON content changes dynamically and is even transformed. Physical, chemical, thermal, or biological processes physically reduce DON content. Temperature, heating time, enzymes, food additives, microorganisms, food composition, contamination level, and other ingredients are key factors. Although DON content can be reduced during food processing, increases in other toxins, such as DON‐3‐β‐d‐glucoside and 3‐acetyl‐DON, can be potentially risky. The application of biodegradation methods in food processing bears research significance. Both microorganisms and enzymes can be potentially used. Novel techniques, such as RNA interference, omics technologies, or enzymes coupled with the genetic engineering method, can be introduced. This review systematically updates the understanding of masked forms of DON, biological degradation strategy, fate of DON during processing, and future trends for biodegradation. Challenges to the successful application of biological methods may include the stability and suitability of the detoxification agents, security of degradation products, and successful application for industrial production.

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Innovative Strategies in the Control of T‐2 and HT‐2 Toxins in Food and Feed

Basaiah,

Nayak,

Veeranna

2023

Anti‐Mycotoxin Strategies for Food and Feed

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Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

Cited by 72 publications

References 58 publications

Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol

Deoxynivalenol: Masked forms, fate during food processing, and potential biological remedies

Innovative Strategies in the Control of T‐2 and HT‐2 Toxins in Food and Feed

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