Detoxification of nerve agents by a substituted β-cyclodextrin: Application of a modified biological assay

Wille, Timo; Tenberken, Oliver; Reiter, Georg; Müller, Susanne; Provost, Romain Le; Lafont, Olivier; Estour, François; Thiermann, Horst; Worek, Franz

doi:10.1016/j.tox.2009.09.018

Cited by 42 publications

(25 citation statements)

References 22 publications

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“…24 The authors state the ability of IBA-bCD to detoxify the nerve agents tested decreases in the following order: GF > GB > GA c VX, in agreement with the earlier reports discussed above. 24 The authors state the ability of IBA-bCD to detoxify the nerve agents tested decreases in the following order: GF > GB > GA c VX, in agreement with the earlier reports discussed above.…”

Section: Recognition Of G-series Agents By Cyclodextrinssupporting

confidence: 88%

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing

2013

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Supramolecular chemistry presents many possible avenues for the mitigation of the effects of chemical warfare agents (CWAs), including sensing, catalysis and sequestration. To-date, efforts in this field both to study fundamental interactions between CWAs and to design and exploit host systems remain sporadic. In this tutorial review the non-covalent recognition of CWAs is considered from first principles, including taking inspiration from enzymatic systems, and gaps in fundamental knowledge are indicated. Examples of synthetic systems developed for the recognition of CWAs are discussed with a focus on the supramolecular complexation behaviour and non-covalent approaches rather than on the proposed applications.

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Section: Recognition Of G-series Agents By Cyclodextrinssupporting

confidence: 88%

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing

2013

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“…Compound 26c was therefore selected to evaluate its efficiency against chemical warfare agents using a biological enzymatic assay [ 91 ]. The ability and the detoxification rate decreases in the order cyclosarin > sarin > tabun and no activity is observed against VX.…”

Section: Reviewmentioning

confidence: 99%

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

Letort¹,

Balieu²,

Erb³

et al. 2016

Beilstein J. Org. Chem.

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SummaryThe aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target.

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“…The uses of β-CD are important as a macrocyclic host-guest interaction for many sensor applications including DNA, sugar, and CNAs because of their natural, water-soluble native. 22,29,30 They have been evaluated to have the ability to detoxify various OP compounds and in the future, they could be used as prophylactic or antidote substances. 30,31 Herein, we incorporated β-CD molecules into the polymerized network of polyacrylamide during the PCCA fabrication process.…”

Section: Detection Of Paraoxon-ethyl and Parathion-ethyl Using Pcca Tmentioning

confidence: 99%

“…22,29,30 They have been evaluated to have the ability to detoxify various OP compounds and in the future, they could be used as prophylactic or antidote substances. 30,31 Herein, we incorporated β-CD molecules into the polymerized network of polyacrylamide during the PCCA fabrication process. The basic sensing unit consists of β-CD recognition element that can bind to OP compounds through hydrogen bonding interactions, and van der Waals forces.…”

Section: Detection Of Paraoxon-ethyl and Parathion-ethyl Using Pcca Tmentioning

confidence: 99%

Fabrication of Polymerized Crystalline Colloidal Array Thin Film Modified β-Cyclodextrin Polymer for Paraoxon-ethyl and Parathion-ethyl Detection

Bui

Seo

2014

ANAL. SCI.

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We have developed an optical chemical sensor for the detection of organophosphate (OP) compounds using a polymerized crystalline colloidal array (PCCA) thin film composed of a close-packed colloidal array of polystyrene particles. The PCCA thin film was modified with β-cyclodextrin (β-CD) polymer as a capping cavity for the selective detection of paraoxon-ethyl and parathion-ethyl chemical agents. The fabrication of the modified PCCA thin film was optimized and the structure was characterized using scanning electron microscopy (SEM). The arrangement of polystyrene particles in the PCCA follows a pattern of the fcc (111) planes with strong diffraction peak in the visible spectral region and pH dependence. The diffraction peak of the β-CD modified PCCA thin film showed a red shift according to the change of paraoxon-ethyl and parathion-ethyl concentrations at a fast response time (10 s) and high sensitivity with detection limits of 2.0 and 3.4 ppb, respectively. Furthermore, the proposed interaction mechanism of β-CD with paraoxon-ethyl and parathion-ethyl in the β-CD modified PCCA thin film were discussed.

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Detoxification of nerve agents by a substituted β-cyclodextrin: Application of a modified biological assay

Cited by 42 publications

References 22 publications

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

Fabrication of Polymerized Crystalline Colloidal Array Thin Film Modified β-Cyclodextrin Polymer for Paraoxon-ethyl and Parathion-ethyl Detection

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