Detox shampoos for EtG and FAEE in hair – Results from in vitro experiments

Luginbühl, Marc; Bekaert, Boris; Suesse, Silke; Stöth, Frederike; Weinmann, Wolfgang

doi:10.1016/j.toxac.2019.03.019

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Thereby, PEth's strength as a direct alcohol biomarker lies in recognizing these drinking habits (during the past 2–4 weeks) rather than the detection of a single drinking event with limited quantities of alcohol. Compared to the analysis of EtG in hair, which serves as a widely applied cumulative long‐term alcohol biomarker, the analysis of PEth is significantly less labor‐intensive and does not have the potential of presampling manipulation (Luginbühl et al, 2018; Luginbühl, Bekaert, et al, 2019). Compared to indirect alcohol biomarkers such as gamma‐glutamyltransferase (GGT) in serum or plasma and carbohydrate‐deficient transferrin (CDT) in serum or blood, PEth has been demonstrated to be more sensitive and selective (Andresen‐Streichert et al, 2017; Hartmann et al, 2007; Helander et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Current evolutions, applications, and challenges of phosphatidylethanol analysis for clinical and forensic purposes

Luginbühl¹,

Uytfanghe

Stöth

et al. 2022

WIREs Forensic Science

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Phosphatidylethanols (PEth) are a group of abnormal phospholipids which are formed within the human body in the presence of ethanol. As PEth accumulates in red blood cells, which prolongs its detectability, it became popular as a direct alcohol biomarker. When alcohol is consumed regularly, PEth concentrations in the human blood reach an equilibrium (plateau) between formation and degradation which is representative of drinking habits. A wide range of applications has been demonstrated for PEth, whereby in most studies it could provide advancements regarding accuracy and precision when compared to already established alcohol biomarkers (carbohydrate-deficient transferrin, gamma-glutamyltransferase, and ethyl glucuronide). Although PEth has been the focus of many research projects all around the world, the final breakthrough from the research laboratory into the clinical mass market is still ongoing. In this overview article, we discuss the evolution of PEth analysis, its applications, and the associated challenges. The main reasons that hinder the use of PEth in the mass market were identified as (a) the lack of implementing a uniform reference measurement system, which should ensure that every single PEth result is comparable and/or (b) ensuring good laboratory practice dedicated to PEth analysis, which should guarantee that every result obtained by an individual laboratory is correct. These challenges regarding PEth analytics must be carefully addressed in the near future before the implementation of common cut-off values and international guidelines can take place.

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Section: Introductionmentioning

confidence: 99%

Current evolutions, applications, and challenges of phosphatidylethanol analysis for clinical and forensic purposes

Luginbühl¹,

Uytfanghe

Stöth

et al. 2022

WIREs Forensic Science

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“…After a single application of a detox shampoo, no notable impact on the EtG levels has been observed ( Binz et al ., 2014 ). However, repetitive and prolonged incubation can decrease EtG concentrations in hair ( Luginbuhl et al ., 2019 ). Misleading hair testing results can also be caused by falsely elevated concentrations after hair treatment with EtG-containing cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Use of Ethanol-Based Hand Disinfectants: Source of Increased Ethyl Glucuronide Levels in Hair?

Scholz

Baumgartner

Madry

2020

Alcohol and Alcoholism

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Aim Due to the COVID-19 pandemic increasing the use of hand disinfectants, we investigated the effect of frequent use of ethanol-based hand disinfectants (EBHD) on the levels of the alcohol marker ethyl glucuronide (EtG) in hair. Method Hair samples were collected from 10 health professionals (8 nondrinkers, 2 rarely drinking individuals) and EtG was examined in hair. Result EtG (~2 pg/mg) was only detected in the hair sample of a nondrinker using EBHD 60–70 times per working day. Conclusion Our data provide no evidence that frequent EBHD use results in hair EtG levels above the recommended Society of Hair Testing cutoff for repeated alcohol consumption (5 pg/mg).

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Detox shampoos for EtG and FAEE in hair – Results from in vitro experiments

Cited by 2 publications

References 3 publications

Current evolutions, applications, and challenges of phosphatidylethanol analysis for clinical and forensic purposes

Current evolutions, applications, and challenges of phosphatidylethanol analysis for clinical and forensic purposes

Use of Ethanol-Based Hand Disinfectants: Source of Increased Ethyl Glucuronide Levels in Hair?

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