Deterrency of Mexican Bean Beetle (Coleoptera: Coccinellidae) Feeding by Free Phenolic Acids

Fischer, Daniel C.; Kogan, Marcos; Paxton, J. D.

doi:10.18474/0749-8004-25.2.230

Cited by 11 publications

(2 citation statements)

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“…Also, ferulic acid was shown to be involved in maize resistance to the weevil Sitophilus zeamais (Classen et al, 1990). More than half of the common phenolic acids that were tested reduced feeding of the Mexican bean beetle (Coccinellidae) when sprayed on to leaves of its preferred host, the common bean Phaseolus vulgaris (Fischer et al, 1990). Additionally, high levels of phenolic acid content in the older leaves (0.3-1.0%) of Sorghum bicolor significantly reduced feeding by Locusta migratoria (Woodhead and Cooper-Driver, 1979).…”

Section: Biological Activitymentioning

confidence: 99%

Chemistry of Cirsium and Carduus: a role in ecological risk assessment for biological control of weeds?

Jordon‐Thaden

Louda

2003

Biochemical Systematics and Ecology

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Prediction of host plant range and ecological impact of exotic phytophagous insects, such as insects for classical biological control of weeds, represents a major challenge. Recently, the flowerhead weevil (Rhinocyllus conicus Fröl.), introduced from Europe into North America to control exotic thistles (Carduus spp.), has become invasive. It feeds heavily on some, but not all species of native North American thistles (Cirsium spp.). We hypothesized that such non-target use among native plants could be better predicted by knowledge of characteristic chemical profiles of secondary compounds to supplement the results of host specificity testing. To evaluate this hypothesis, we reviewed the literature on the chemistry of Cirsium and Carduus thistles. We asked what compounds are known to be present, what is known about their biological activity, and whether such information on chemical profiles would have better predicted realized host range and ecological effects of R. conicus in North America. We found an extensive, but incomplete literature on the chemistry of true thistles. Two main patterns emerged. First, consistent chemical similarities and interesting differences occur among species of thistles. Second, variation occurs in biologically active groups of characteristic compounds, specifically flavonoids, sterols, alkaloids and phenolic acids, that are known to influence host plant acceptance, selection, and feeding by phytophagous insects. Surprisingly, sesquiterpene lactones, which are characteristic in closely related Asteraceae, have not been extensively reported for Cirsium or Carduus. The minimal evidence on sesquiterpene lactones may reflect extraction methods vs. true absence. In summary, our review suggests further research on thistle chemistry in insect feeding is warranted. Also, since the exotic Canada thistle (Cirsium arvense) is an invasive thistle of current concern in North America, such research on mechanisms underlying host range expansion by exotic insects would be useful.

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Section: Biological Activitymentioning

confidence: 99%

Chemistry of Cirsium and Carduus: a role in ecological risk assessment for biological control of weeds?

Jordon‐Thaden

Louda

2003

Biochemical Systematics and Ecology

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“…On the basis of these rules we have since searched for further potential candidates to inhibit FGFs, examining different libraries of natural products. We found that gentisic acid (GA; 2,5-dihydroxybenzoic acid), a widespread plant secondary metabolite involved in pest defense and a catabolite of aspirin, is a potential inhibitor of FGF (27)(28)(29)(30)(31)(32). Here we show that GA does indeed define a new chemical group of FGF inhibitors, which includes homogentisic acid (HGA; 2-(2,5-dihydroxyphenyl)acetic acid), the toxic agent in alkaptonuria.…”

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confidence: 92%

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Fernandez

Cuevas

Angulo

et al. 2010

Journal of Biological Chemistry

106

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Fibroblast growth factors are key proteins in many intercellular signaling networks. They normally remain attached to the extracellular matrix, which confers on them a considerable stability. The unrestrained accumulation of fibroblast growth factors in the extracellular milieu, either due to uncontrolled synthesis or enzymatic release, contributes to the pathology of many diseases. Consequently, the neutralization of improperly mobilized fibroblast growth factors is of clear therapeutic interest. In pursuing described rules to identify potential inhibitors of these proteins, gentisic acid, a plant pest-controlling compound, an aspirin and vegetarian diet common catabolite, and a component of many traditional liquors and herbal remedies, was singled out as a powerful inhibitor of fibroblast growth factors. Gentisic acid was used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it was shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis. In addition, we obtained evidence from in vivo disease models that this group of inhibitors may be of interest to treat cancer and angiogenesis-dependent diseases.The fibroblast growth factors (FGFs) 4 constitute one of the largest families of polypeptide growth factors. There are 22FGFs in humans and mice that differ significantly in both size (17-20 kDa) and sequence, although each contains a core homology region encompassing 120 -130 residues. Phylogenetic analyses suggest that the FGF genes can be arranged into seven subfamilies. All FGFs bind to heparin with high affinity (K d between 1-2 nM), except for the members of the FGF-19 subfamily (i.e.: FGF-15, -19, -21, and -23) that have little or no affinity for these glycosaminoglycans (1). Apart from the family comprising FGF-11 to FGF-14, FGFs exert their diverse biological actions by binding to a series of membrane tyrosine kinase receptors (FGFRs) that are encoded by four genes (2-4). For this reason the FGF family is currently considered to be constituted by 18 members.FGFs were first isolated in the 1980s from bovine brain extracts due to their mitogenic and angiogenic activities (5). The affinity of FGFs for heparin was recognized very soon after their discovery (6), although the physiological substrate for FGF in normal conditions is heparan sulfate, a proteoglycan whose glycoside moiety is a glycosaminoglycan like heparin. Although initially conceived as FGF traps and protectors, it was later shown that these proteoglycans also participate in FGF signaling, although they are not absolutely required (4,7,8).In addition to the effects on cell replication and angiogenesis observed initially, FGFs r...

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Elicitor-mediated induction of isochorismate synthase and accumulation of 2,3-dihydroxy benzoic acid in Catharanthus roseus cell suspension and shoot cultures

1994

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After elicitation, cell suspension cultures of Catharanthus roseus accumulate phenolic compounds. The major phenolic compound produced was isolated and identified as 2,3-dihydroxybenzoic acid (DHBA). The accumulation of this compound is a rapid response to the addition of elicitor; within 6 h after the addition of elicitor, DHBA concentration reached 6.3 mg/l cell suspension. DHBA was not detected in non-elicited cells. The formation of DHBA in elicited cells was correlated with the induction of the enzyme isochorismate synthase (ICS). Shoot cultures of C. roseus also presented a strong induction of ICS after elicitation. Due to its biological activity, DHBA could play a role in the defence mechanism of C. roseus.

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Deterrency of Mexican Bean Beetle (Coleoptera: Coccinellidae) Feeding by Free Phenolic Acids

Cited by 11 publications

References 0 publications

Chemistry of Cirsium and Carduus: a role in ecological risk assessment for biological control of weeds?

Chemistry of Cirsium and Carduus: a role in ecological risk assessment for biological control of weeds?

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Elicitor-mediated induction of isochorismate synthase and accumulation of 2,3-dihydroxy benzoic acid in Catharanthus roseus cell suspension and shoot cultures

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