Deterministic and probabilistic health risk assessment for exposure to non-steroidal anti-inflammatory drugs in an Indian river

Srinivasan, Ramya; Rajasekhar, Bokam; Nambi, Indumathi M.

doi:10.1007/s11356-020-11897-4

Cited by 9 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the probabilistic risk assessment was performed by Monte Carlo simulation considering the distribution fitting and random sampling, and then the simulated results of the best output can be applied for uncertainty and sensitivity assessment ( 42 ). The benefit of the model is that the error of the method is independent of the dimension of the problem, and the distribution of human health risk can be simulated effectively ( 31 ).…”

Section: Methodsmentioning

confidence: 99%

Co-exposure of potentially toxic elements in wheat grains reveals a probabilistic health risk in Southwestern Guizhou, China

Zhang

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Bijie is located at a typical karst landform of Southwestern Guizhou, which presented high geological background values of potentially toxic elements (PTEs). Recently, whether PTE of wheat in Bijie is harmful to human health has aroused people’s concern. To this end, the objectives of this study are to determine the concentrations of PTE [chromium (Cr), nickel (Ni), arsenic (As), lead (Pb), cadmium (Cd), and fluorine (F)] in wheat grains, identify contaminant sources, and evaluate the probabilistic risks to human beings. A total of 149 wheat grain samples collected from Bijie in Guizhou were determined using the inductively coupled plasma mass spectrometer (ICP-MS) and fluoride-ion electrode methods. The mean concentrations of Cr, Ni, As, Cd, Pb, and F were 3.250, 0.684, 0.055, 0.149, 0.039, and 4.539 mg/kg, respectively. All investigated PTEs met the standard limits established by the Food and Agriculture Organization except for Cr. For the source identification, Cr and Pb should be originated from industry activities, while Ni, As, and Cd might come from mixed sources, and F was possibly put down to the high geological background value. The non-carcinogenic and carcinogenic health risks were evaluated by the probabilistic approach (Monte Carlo simulation). The mean hazard quotient (HQ) values in the three populations were lower than the safety limit (1.0) with the exception of As (children: 1.03E+00). However, the mean hazard index (HI) values were all higher than 1.0 and followed the order: children (2.57E+00) > adult females (1.29E+00) > adult males (1.12E+00). In addition, the mean carcinogenic risk (CR) values for Cr, As, Pb, and Cd in three populations were all higher than 1E-06, which cannot be negligible. The mean threshold CR (TCR) values were decreased in the order of children (1.32E-02) > adult females (6.61E-03) > adult males (5.81E-03), respectively, all at unacceptable risk levels. Moreover, sensitivity analysis identified concentration factor (CW) as the most crucial parameter that affects human health. These findings highlight that co-exposure of PTE in wheat grains revealed a probabilistic human health risk. Corresponding measures should be undertaken for controlling pollution sources and reducing the risks for the local populace.

show abstract

Section: Methodsmentioning

confidence: 99%

Co-exposure of potentially toxic elements in wheat grains reveals a probabilistic health risk in Southwestern Guizhou, China

Zhang

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Researchers may conclude that there is no danger based on a deterministic risk assessment, in which case no risk-management measures may be taken. 7,116…”

Section: Approaches To Risk Assessment For Pesticide-related Cancer R...mentioning

confidence: 99%

The role of Pesticides in Cancer initiation and progression: A comprehensive review

Arora,

Kumar,

Kumar

2024

CBL

View full text Add to dashboard Cite

Distribution of Emerging Contaminants, and Antimicrobial Resistance: Occurrence, Toxicity, Risk Assessment, and Removal

Puri

Gandhi

Kumar

2022

Impact of COVID-19 on Emerging Contaminants

View full text Add to dashboard Cite

Deterministic and probabilistic health risk assessment for exposure to non-steroidal anti-inflammatory drugs in an Indian river

Cited by 9 publications

References 32 publications

Co-exposure of potentially toxic elements in wheat grains reveals a probabilistic health risk in Southwestern Guizhou, China

Co-exposure of potentially toxic elements in wheat grains reveals a probabilistic health risk in Southwestern Guizhou, China

The role of Pesticides in Cancer initiation and progression: A comprehensive review

Distribution of Emerging Contaminants, and Antimicrobial Resistance: Occurrence, Toxicity, Risk Assessment, and Removal

Contact Info

Product

Resources

About