Determining the topography of interhemispheric fibres in the human corpus callosum (CC) between the primary motor cortices with a combined fMRI/DTI-fibretracking prodecure

Wahl, Michael; Lauterbach-Soon, Birgit; Hattingen, Elke; Ogrezeanu, G.; Lanfermann, H.; Ziemann, Ulf

doi:10.1055/s-2006-939316

Cited by 2 publications

(3 citation statements)

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“…the posterior body of the CC) in the patients with a pathologically prolonged iSP duration compared to those with a normal iSP duration. This is consistent with recent data in humans that identified the posterior body and isthmus of the CC as the site where the transcallosal fibres connecting the MI of the two hemispheres are located [18,36].…”

Section: Relation Of Isp Measures To Mri Findingssupporting

confidence: 93%

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Jung

Beyerle

Humpich

et al. 2006

Journal of the Neurological Sciences

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Section: Relation Of Isp Measures To Mri Findingssupporting

confidence: 93%

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Jung

Beyerle

Humpich

et al. 2006

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 99%

“…In the human brain, homonymous regions of the primary motor cortices (M1) are connected by transcallosal fibers running through the posterior body and isthmus of the corpus callosum (Wahl et al, 2007). There is evidence that the transcallosal connection between primary motor cortices is mainly inhibitory (Ferbert et al, 1992), such that activity in the M1 of one hemisphere inhibits activity in the other hemisphere.…”

Section: Introductionmentioning

confidence: 99%

Modulating activity in the motor cortex affects performance for the two hands differently depending upon which hemisphere is stimulated

Vines

Nair

Schlaug

2008

Eur J of Neuroscience

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We modulated neural excitability in the human motor cortex to investigate behavioral effects for both hands. In a previous study, we showed that decreasing excitability in the dominant motor cortex led to a decline in performance for the contralateral hand and an improvement for the ipsilateral hand; increasing excitability produced the opposite effects. Research suggests that the ipsilateral effects were mediated by interhemispheric inhibition. Physiological evidence points to an asymmetry in interhemispheric inhibition between the primary motor cortices, with stronger inhibitory projections coming from the dominant motor cortex. In the present study, we examined whether there is a hemispheric asymmetry in the effects on performance when modulating excitability in the motor cortex. Anodal and cathodal transcranial direct current stimulation were applied to the motor cortex of 17 participants, targeting the non-dominant hemisphere on one day and the dominant hemisphere on another day, along with one sham session. Participants performed a finger-sequence coordination task with each hand before and after stimulation. The dependent variable was calculated as the percentage of change in the number of correct keystrokes. We found that the effects of transcranial direct current stimulation depended upon which hemisphere was stimulated; modulating excitability in the dominant motor cortex significantly affected performance for the contralateral and ipsilateral hands, whereas modulating excitability in the non-dominant motor cortex only had a significant impact for the contralateral hand. These results provide evidence for a hemispheric asymmetry in the ipsilateral effects of modulating excitability in the motor cortex and may be important for clinical research on motor recovery.

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Determining the topography of interhemispheric fibres in the human corpus callosum (CC) between the primary motor cortices with a combined fMRI/DTI-fibretracking prodecure

Cited by 2 publications

References 0 publications

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Ipsilateral silent period: A marker of callosal conduction abnormality in early relapsing–remitting multiple sclerosis?

Modulating activity in the motor cortex affects performance for the two hands differently depending upon which hemisphere is stimulated

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