Abstract:Transient receptor potential vanilloid 2 (TRPV2) is a ligand‐gated ion channel that is expressed in cadiomyocytes and increases contractility following stimulation with probenecid, an agonist for TRPV2. However, the subcellular location and mechanism of activation of this receptor are unkown. We used two independent approaches in cardiac‐derived HL‐1 cells to elucidate the localization and mechanism of TRPV2. To study TRPV2‐mediated Ca2+ transport into the cytosol, HL‐1 cells were first treated with a fluoresc… Show more
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