Determining the presence of chemicals with suspected endocrine activity in drinking water from the Madrid region (Spain) and assessment of their estrogenic, androgenic and thyroidal activities

Valcárcel, Y.; Valdehíta, Ana; Becerra, Eva María Fagundo; Alda, Miren López de; Gil, Á.; Gorga, Marina; Petrović, Mira; Barceló, Damià; Navas, José M.

doi:10.1016/j.chemosphere.2018.02.099

Cited by 52 publications

(22 citation statements)

References 63 publications

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“…In many cases, estrogenic activity was below the assay detection limit after treatment. While less studied, other types of hormonal activity, such as activation of the androgen receptor (AR), progesterone receptor (PR), glucocorticoid receptor (GR) and thyroid receptor (TR), have not been detected in drinking water [1,11,12,[26][27][28], with the exception of low androgenic activity in one drinking water sample from the Netherlands [29].…”

Section: Application Of In Vitro Bioassays To Drinking Watermentioning

confidence: 99%

In vitro bioassays to assess drinking water quality

Neale

Escher

2019

Current Opinion in Environmental Science & Health

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In vitro assays indicative of different stages of cellular toxicity pathways have been applied to both source water and drinking water. The majority of studies showed a decrease in receptor-mediated effects after drinking water treatment due to the removal of micropollutants, while reactive toxicity typically increased after chlorination due to the formation of disinfection byproducts. Using both chemical analysis and bioanalysis, iceberg modelling can be applied to determine which chemicals are contributing to the observed effect, though one limitation is that typical sample pretreatment for bioanalysis fails to capture volatile chemicals. Bioassays are increasingly sensitive and effects can be detected in clean samples, thus effect-based trigger values can be applied to determine whether an effect in drinking water is acceptable.

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Section: Application Of In Vitro Bioassays To Drinking Watermentioning

confidence: 99%

In vitro bioassays to assess drinking water quality

Neale

Escher

2019

Current Opinion in Environmental Science & Health

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“…Pharmacological active chemicals have been detected in drinking water and other water resources [ 1 , 2 ] and their negative effects on various organisms have been observed [ 3 , 4 ]. 17

-Estradiol (E2), for example, has been detected in low concentrations between 0.1 and 3.6 ng·L

in different water samples [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Detailed Analysis of 17β-Estradiol-Aptamer Interactions: A Molecular Dynamics Simulation Study

Eisold

Labudde

2018

Molecules

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Micro-pollutants such as 17β-Estradiol (E2) have been detected in different water resources and their negative effects on the environment and organisms have been observed. Aptamers are established as a possible detection tool, but the underlying ligand binding is largely unexplored. In this study, a previously described 35-mer E2-specific aptamer was used to analyse the binding characteristics between E2 and the aptamer with a MD simulation in an aqueous medium. Because there is no 3D structure information available for this aptamer, it was modeled using coarse-grained modeling method. The E2 ligand was positioned inside a potential binding area of the predicted aptamer structure, the complex was used for an 25 ns MD simulation, and the interactions were examined for each time step. We identified E2-specific bases within the interior loop of the aptamer and also demonstrated the influence of frequently underestimated water-mediated hydrogen bonds. The study contributes to the understanding of the behavior of ligands binding with aptamer structure in an aqueous solution. The developed workflow allows generating and examining further appealing ligand-aptamer complexes.

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“…This is relevant for drinking water where chemicals are often present at low concentrations, potentially below analytical detection limits, but the mixture effects of the many chemicals present at trace levels may still be significant. 6 Several studies have applied bioassays indicative of induction of xenobiotic metabolism, 7 receptormediated effects, 8,9 adaptive stress responses 10,11 and reactive modes of action 12 to assess drinking water quality, though estrogenic activity is the most commonly studied endpoint. Most studies reported decreased estrogenic activity after drinking water treatment, with either no or low estrogenic activity in treated water, 8,13 though Rosenmai et al 14 found no change in estrogenic activity in one water treatment plant (WTP).…”

Section: Introductionmentioning

confidence: 99%