Determining the optical properties of turbid media by using the adding–doubling method

Prahl, Scott A.; Gemert, Martin J. C. van; Welch, Ashley J.

doi:10.1364/ao.32.000559

Cited by 811 publications

(592 citation statements)

References 33 publications

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“…This is achieved by iteratively solving the forward problem with improved estimations of the radiative properties until the calculated value converges to the experiment result. 35,36 …”

Section: Modelingmentioning

confidence: 99%

Modeling silica aerogel optical performance by determining its radiative properties

et al. 2016

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Silica aerogel has been known as a promising candidate for high performance transparent insulation material (TIM). Optical transparency is a crucial metric for silica aerogels in many solar related applications. Both scattering and absorption can reduce the amount of light transmitted through an aerogel slab. Due to multiple scattering, the transmittance deviates from the Beer-Lambert law (exponential attenuation). To better understand its optical performance, we decoupled and quantified the extinction contributions of absorption and scattering separately by identifying two sets of radiative properties. The radiative properties are deduced from the measured total transmittance and reflectance spectra (from 250 nm to 2500 nm) of synthesized aerogel samples by solving the inverse problem of the 1-D Radiative Transfer Equation (RTE). The obtained radiative properties are found to be independent of the sample geometry and can be considered intrinsic material properties, which originate from the aerogel’s microstructure. This finding allows for these properties to be directly compared between different samples. We also demonstrate that by using the obtained radiative properties, we can model the photon transport in aerogels of arbitrary shapes, where an analytical solution is difficult to obtain.

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“…This is achieved by iteratively solving the forward problem with improved estimations of the radiative properties until the calculated value converges to the experiment result. 35,36 …”

Section: Modelingmentioning

confidence: 99%

Modeling silica aerogel optical performance by determining its radiative properties

et al. 2016

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“…An integrating sphere (Labsphere, North Sutton, NH) was used to determine the transmittance and reflectance of 635 nm laser diode light in rodent skin samples [15,16]. The skin/glass combination was placed at the entrance and exit ports of the integrating sphere for transmittance and reflectance measurements, respectively.…”

Section: Tissue Optical Clearing Measurementmentioning

confidence: 99%

“…System calibration was performed using neutral density filters and reflectance standards (Labsphere). The inverse-adding-doubling method was used to calculate the reduced scattering coefficient, m 0 s , for each skin sample before and after clearing agent application [16]. Volume matched solutions of each clearing agent were applied to the dermal side of the skin sample.…”

Section: Tissue Optical Clearing Measurementmentioning

confidence: 99%

Correlation between collagen solubility and skin optical clearing using sugars

et al. 2007

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Background and Objective: Light scattering from collagen within skin limits light-based therapeutics while increasing the risk of epidermal thermal injury. Specific chemicals show the ability to reduce light scattering by reversibly altering the optical properties of skin. This study examines the correlation between collagen solubility and the optical clearing potential (OCP) of sugars and sugar-alcohols using in vitro rodent skin. Materials and Methods: Collagen solubility in dextrose, fructose, sucrose, and sorbitol was measured using near-UV spectroscopy. Light transmittance, reflectance, and rodent skin thickness were measured (giving skin reduced scattering coefficient) before and after exposure of the dermal surface to sugars and sugar-alcohols. OCP was calculated as the ratio of reduced scattering coefficients before and after exposures. Results: Dextrose, fructose, sucrose, and sorbitol had at least twice the collagen solubility and twice the OCP as compared to glycerol. In general, collagen solubility correlated with each agent's ability to optically clear rodent skin.Conclusion: These results demonstrate that sugar and sugar-alcohol interaction with collagen are a primary event in tissue optical clearing.

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“…To measure the optical properties (diffuse transmission and surface reflectance) of freshly excised in vitro human skin, an integrating sphere was used [6] with an inverse adding doubling algorithm [7] to estimate the reduced scattering coefficient ( s ') of the samples. The optical clearing potential (OCP) was defined as the ratio of m s ' immediately before and 24 hours after, agent application.…”

mentioning

confidence: 99%

Optical clearing of in vivo human skin: Implications for light‐based diagnostic imaging and therapeutics

et al. 2004

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Determining the optical properties of turbid media by using the adding–doubling method

Cited by 811 publications

References 33 publications

Modeling silica aerogel optical performance by determining its radiative properties

Modeling silica aerogel optical performance by determining its radiative properties

Correlation between collagen solubility and skin optical clearing using sugars

Optical clearing of in vivo human skin: Implications for light‐based diagnostic imaging and therapeutics

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