Determining the mechanism of inhibition of mitochondrial Ca2+ overload by the cocoa flavanol (‐)‐epicatechin as a means of conferring cardioprotection during ischemia‐reperfusion
Abstract:A diet rich in flavonoids has been shown to have a negative correlation with the incidence of cardiovascular disease. Epicatechin (EPI), a cocoa flavonoid, reduced infarct size and improved long‐term left ventricular structure and function post ischemia reperfusion (IR) by significantly inhibiting mitochondrial calcium (Ca2+) overload, a process that induces apoptosis. However, the mechanism is not known. Our objective is to determine the mechanisms by which EPI inhibits Ca2+overload using an in vitro model of… Show more
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