Determining the Levels of Matrix Metalloproteinase-9 in Portal and Peripheral Blood is Useful for Predicting Liver Metastasis of Colorectal Cancer

Ishida, Hideyuki; Murata, Nobuo; Tada, Mitsuru; Okada, Nobuhiro; Hashimoto, Daijo; Kubota, Shunichiro; Shirakawa, Kazuo; Wakasugi, Hiro

doi:10.1093/jjco/hyg035

Cited by 23 publications

(15 citation statements)

References 15 publications

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“…In human colorectal adenocarcinomas, the MMP-9 mRNA and the MMP-9 plasma protein levels are also increased compared with normal individuals (12,13). Interestingly, increased MMP-9 protein level measured in portal blood versus that measured in the peripheral blood has been reported to predict liver metastasis (14). By histologic localization studies, we and others have found previously that MMP-9 mRNA and/or protein are induced in a small subpopulation of macrophages located at the invasive front in the vicinity of the invasive cancer cells, suggesting that the MMP-9-expressing macrophages are important for the invasion of cancer cells into the normal tissues (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

Illemann¹,

Bird

Majeed

et al. 2006

Molecular Cancer Research

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Matrix metalloproteinase-9 (MMP-9) is up-regulated in macrophages in various human cancer types. In human colon cancer, MMP-9 is expressed in a macrophage subpopulation located at the tumor edge, indicating a specific induction of MMP-9 in macrophages in direct association with cancer invasion. To test whether MMP-9 is also induced in tumor edge macrophages in metastases from colorectal adenocarcinomas, we have compared the expression pattern of MMP-9 in primary colorectal adenocarcinomas (n = 15) with that in liver metastases (n = 15) and local lymph node metastases (n = 7) from the same patients by in situ hybridization and immunohistochemistry. In all the colorectal adenocarcinomas, the expression of MMP-9 mRNA and immunoreactivity in macrophages was located at the invasive front. In contrast, only 3 of the 15 liver metastases had MMP-9 mRNA and immunoreactivity at the periphery, and this expression was confined to small foci of macrophages located either among lymphocytes or in a dense desmoplastic stroma. Expression of MMP-9 mRNA and immunoreactivity was in all liver metastases seen in macrophages located in the lumen of malignant glandular structures and in central necrotic tissue. In all the 7 lymph node metastases, MMP-9 mRNA and immunoreactivity was seen in macrophages located in the stromal tissue surrounding the metastases. We conclude that MMP-9 is not up-regulated in tumor edge macrophages in liver metastases like in their primary tumor and local lymph node metastases, suggesting that disseminating colorectal cancer cells can adopt alternative proteolytic mechanisms for invasion depending on the local microenvironment. (Mol Cancer Res 2006;4(5):293 -302)

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Section: Introductionmentioning

confidence: 99%

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

Illemann¹,

Bird

Majeed

et al. 2006

Molecular Cancer Research

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“…In cancer immunology, a clear role of MMP7 and of other MMPs has been shown in tumour growth and invasion (17,(20)(21)(22)(23)(24)(25). Increased MMP7 expression in tumour tissue, serum, lymph nodes and peritoneal liquid generally correlates with worse prognosis, a tendency for metastatic disease and reduced overall survival (18,(26)(27)(28)(29)(30)(31)(32). This suggests a possible role for MMP7 in the determination of locally advanced cancer in resected specimens, and in staging and planning for eventual adjuvant therapy, attesting to a potential role of MMP7 as prognostic factor and tumour marker (33) The effect of RT on MMP7 gene in human rectal cancer was first investigated in vivo by Kumar et al, who observed overexpression of MMP7 in radiated rectal cancer tissue compared to nearby irradiated normal rectal tissue (9).…”

Section: Discussionmentioning

confidence: 99%

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

Stene

Polistena

Gaber

et al. 2018

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“…MMPs participate in other processes infl uencing the primary tumour growth, angiogenesis and invasion, intra-and extravasation of metastatical cells and growth of metastatic process (19). The synchronous determination of the levels of MMP-9 in portal and peripheral blood is useful for selecting colorectal cancer patients at high risk of hepatic recurrence (20). TIMP-1 and -2 and MMP-2 were detected during tissue regeneration in rats while MMP-3, -9, -10, -13 and -14 were not (21).…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinases and their inhibitors in correlation to proliferative and classical tumour markers during surgical therapy of colorectal liver metastases

Liška

Sutnar²,

Holubec³

et al. 2012

BLL

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Abstract:Objectives: Classical and proliferative tumour markers and matrix metalloproteinases and their tissue inhibitors refl ect the features of malignancy and are useful in prediction of prognosis in patients with colorectal liver metastases. There is very limited information about their physiological functions during regeneration and healing of liver parenchyma after any type of liver surgery for malignancy. Methods: The presented study included the patients, who underwent following surgical procedures for CLM, benign liver lesions and inguinal hernias: Group A: 22 patients with inguinal hernias, Group B: 26 patients with benign liver lesions, Group C: 30 patients with colorectal liver metastases (CLM) who were treated by radiofrequency ablation, Group D: 41 patients with CLM who underwent a radical surgical therapy -resection, and Group E: 22 patients with inoperable CLM who underwent an explorative laparotomy without any surgical procedure. Results: The preoperative and postoperative serum levels of CEA, CA 19-9, TK, TPA, TPS, MMP-2, MMP-9, TIMP-1, and TIMP-2 were statistically analyzed and compared within the groups to estimate the infl uence of a surgical procedure type. These results refl ect the infl uence of surgical procedure on the serum levels of studied tumour markers during operation. Conclusions: It was the fi rst description using these types of comparison to all metalloproteinases, their inhibitors, and proliferative and classical tumour markers. It could help us to estimate the critical relations of these tumour markers in prognoses of disease free survival or overall survival in patients after a surgical procedure for CLM (Tab. 5, Ref. 26). Full Text in PDF www.elis.sk.

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Determining the Levels of Matrix Metalloproteinase-9 in Portal and Peripheral Blood is Useful for Predicting Liver Metastasis of Colorectal Cancer

Abstract: The results suggest that synchronous determination of the levels of MMP-9 in portal and peripheral blood would be useful for selecting colorectal cancer patients at high risk of hepatic recurrence.

Cited by 23 publications

References 15 publications

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer

Matrix metalloproteinases and their inhibitors in correlation to proliferative and classical tumour markers during surgical therapy of colorectal liver metastases

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