Determining the effects of a mixture of an endocrine disrupting compound, 17α-ethinylestradiol, and ammonia on fathead minnow (Pimephales promelas) reproduction

Armstrong, Brandon M.; Lazorchak, James M.; Murphy, Cheryl A.; Haring, Herman J.; Jensen, Kathleen; Smith, Mark E.

doi:10.1016/j.chemosphere.2014.06.049

Cited by 14 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of nitrogen compounds on the reproduction of fish are not clear. In females of Pimephales promelas, the ammonium can both reduce the production of eggs (Armstrong et al 2012) as it may not have any effect (Armstrong et al 2015). In this same species, although it appears that chronic exposure to nitrates can induce a vitellogenic induction in both sexes, it has not been shown that it has effects on the GSI or that it favors the occurrence of intersex between males (Kellock et al 2018).…”

Section: Discussionmentioning

confidence: 91%

Effects of industrial pollution on the reproductive biology of Squalius laietanus (Actinopterygii, Cyprinidae) in a Mediterranean stream (NE Iberian Peninsula)

Soler

Solé

Bañón

et al. 2019

Fish Physiol Biochem

View full text Add to dashboard Cite

Mediterranean rivers are severely affected by pollutants from industry, agriculture and urban activities. In this study we examined how industrial pollutants, many of them known to act as endocrine disruptors (EDCs), could disturb the reproduction of the Catalan chub (Squalius laietanus). The survey was conducted throughout the reproductive period of S. laietanus (from March to July 2014) downstream an industrial WWTP located in the River Ripoll (NE Iberian Peninsula). Eighty fish (28 females and 52 males) were caught by electrofishing upstream and 77 fish (33 females and 44 males) downstream a WWTP. For both sexes, the gonadosomatic index (GSI) and gonadal histology were examined and related to water chemical analysis and fish biomarkers. Female fecundity was assessed using the gravimetric method. Fish from the polluted site showed enhanced biomarker responses involved in detoxification. Also, in the polluted site, lower GSI values were attained in both sexes and females displayed lower numbers of vitellogenic oocytes. Gonadal histology showed that all maturation stages of testicles and ovaries were present at the two study sites but fish males from the polluted site had smaller diameter seminiferous tubules. Water chemical analysis confirmed greater presence of EDCs in the river downstream the industrial WWTP. The chemicals benzotriazole and benzothiazole could be partially responsible for the observed alterations in the reproductive biology of S. laietanus.

show abstract

Section: Discussionmentioning

confidence: 91%

Effects of industrial pollution on the reproductive biology of Squalius laietanus (Actinopterygii, Cyprinidae) in a Mediterranean stream (NE Iberian Peninsula)

Soler

Solé

Bañón

et al. 2019

Fish Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…rutilus) to undiluted effluents or to 4–6 ng/L EE2 over the period of sexual development , have been shown to result in full sex reversal and/or breeding failure. Long-term laboratory exposures to lower concentrations of 0.47–1 ng/L EE2 (predicted for rivers heavily dominated with WwTW effluents) have resulted in female-skewed sex ratios and decreased egg fertilization for several fish species. − Furthermore, dosing of a lake in Canada with 4–6 ng/L EE2 over a period of three years resulted in the collapse of the fathead minnow (Pimephales promelas) population, which subsequently recovered after removal of EE2 …”

Section: Introductionmentioning

confidence: 99%

Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers

Hamilton

Lockyer

Webster

et al. 2020

Environ. Sci. Technol.

View full text Add to dashboard Cite

Exposure of male fish to estrogenic substances from wastewater treatment works (WwTWs) results in feminization and reduced reproductive fitness. Nevertheless, selfsustaining populations of roach (Rutilus rutilus) inhabit river stretches polluted with estrogenic WwTW effluents. In this study we examine whether such roach populations have evolved adaptations to tolerate estrogenic pollution by comparing frequency differences in single nucleotide polymorphisms (SNPs) between

show abstract

“…Reproductive impairments, including feminization of male fish and reduced reproductive success, have been demonstrated in the lab after exposure to concentrations of steroid estrogens within environmentally relevant ranges (e.g. EE2 ranging from < 1 ng L -1 up to 5 ng L -1 (Nash et al 2004;Parrott & Blunt 2005;Lange et al 2008;Zha et al 2008;Armstrong et al 2015)) and the incidence and severity of intersex (occurrence of ovo-testis) in male roach sampled from a series of UK Rivers is significantly correlated with predicted concentrations of steroid estrogens (EE2 concentrations ranging from 0 to 0.37 ng L -1 (Jobling et al 2005)).…”

Section: Exposure To Edcs and Potential Consequences In Fishmentioning

confidence: 99%

Capturing ecology in modeling approaches applied to environmental risk assessment of endocrine active chemicals in fish

Mintram

Brown

Maynard

et al. 2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

Endocrine active chemicals (EACs) are widespread in freshwater environments and both laboratory and field based studies have shown reproductive effects in fish at environmentally relevant exposures. Environmental risk assessment (ERA) seeks to protect wildlife populations and prospective assessments rely on extrapolation from individual-level effects established for laboratory fish species to populations of wild fish using arbitrary safety factors. Population susceptibility to chemical effects, however, depends on exposure risk, physiological susceptibility, and population resilience, each of which can differ widely between fish species. Population models have significant potential to address these shortfalls and to include individual variability relating to life-history traits, demographic and density-dependent vital rates, and behaviors which arise from inter-organism and organism-environment interactions. Confidence in population models has recently resulted in the EU Commission stating that results derived from reliable models may be considered when assessing the relevance of adverse effects of EACs at the population level. This review critically assesses the potential risks posed by EACs for fish populations, considers the ecological factors influencing these risks and explores the benefits and challenges of applying population modeling (including individual-based modeling) in ERA for EACs in fish. We conclude that population modeling offers a way forward for incorporating greater environmental relevance in assessing the risks of EACs for fishes and for identifying key risk factors through sensitivity analysis. Individual-based models (IBMs) allow for the incorporation of physiological and behavioral endpoints relevant to EAC exposure effects, thus capturing both direct and indirect population-level effects.

show abstract

Determining the effects of a mixture of an endocrine disrupting compound, 17α-ethinylestradiol, and ammonia on fathead minnow (Pimephales promelas) reproduction

Cited by 14 publications

References 26 publications

Effects of industrial pollution on the reproductive biology of Squalius laietanus (Actinopterygii, Cyprinidae) in a Mediterranean stream (NE Iberian Peninsula)

Effects of industrial pollution on the reproductive biology of Squalius laietanus (Actinopterygii, Cyprinidae) in a Mediterranean stream (NE Iberian Peninsula)

Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers

Capturing ecology in modeling approaches applied to environmental risk assessment of endocrine active chemicals in fish

Contact Info

Product

Resources

About