Determining the Association of Benign and Malignant Salivary Gland Tumours with ABO-Rh Blood Groups

Abstract

Introduction 
 Various studies have proposed that some ABO blood groups may be associated with increased risk of cancer. Hence, we decided to conduct this study to investigate the relationship between ABO-Rh blood group and risk of salivary gland tumor.
 Materials and Methods
 In this study, 190 patients with salivary gland tumor and 400 healthy persons were investigated. Demographical information including ABO blood group of both groups were collected and analyzed using the SPSS 18 version. Binary logistic regression (univariate and multivariate model) were applied with 95% confidence interval.
 Results
 The most common blood group in patients with salivary gland tumor was blood group O. There was no significant relationship between the ABO blood group and salivary gland tumor risk (All; p>0.05). The blood group O and A were the most abundant blood groups in patients with the malignant and benign salivary gland tumor respectively (46.6%, 35.7%).The risk of malignancy of tumor in the patients with blood group O was marginal (1.84; 95%CI: 0.96-3.53, p: 0.06). 
 Conclusion
 This study shows no relationship between ABO-Rh blood groups and salivary gland tumor risk. However, to reach a definitive conclusion about the risk of malignancy in blood group O, stronger studies are needed in the future.

ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis– A Systematic Review and Meta-Analysis

“…Association of blood Group A in various cancers, including gastric cancers, breast cancers, pancreatic cancers, skin cancers, ovary and oesophageal cancers has been reported in various cohort studies and systematic reviews (Vasan et al, 2016;Mao et al, 2019;Miao et al, 2014;Celic et al, 2019;Huang et al, 2015). The association between ABO blood type with oral cancer and other potentially malignant disorders has also been studied but has yet not been established as risk factors due to contradictory findings (Gupta et al, 2020;Mortazavi et al, 2014;Jaleel and Nagarajappa, 2012;Jalili et al, 2018;Jamil et al, 2006;Kumari et al, 2017;Oroei, 2019;Poornima et al, 2018;Shishodia et al, 2018;Singh et al, 2014;Bhateja et al, 2014).…”

“…Numerous studies have been conducted to assess ABO blood group and its association with oral cancer, other potentially malignant disorders, and oral submucous fibrosis (Gupta et al, 2020;Mortazavi et al, 2014;Jaleel and Nagarajappa, 2012;Jalili et al, 2018;Jamil et al, 2006;Kumari et al, 2017;Oroei, 2019;Poornima et al, 2018;Shishodia et al, 2018;Singh et al, 2014;Bhateja et al, 2014). However, evidence from these studies remains inconclusive.…”