Determining the association between gut microbiota and its metabolites with higher intestinal Immunoglobulin A response

Rajput, Mrigendra; Momin, Tooba; Singh, Amit Kumar; Banerjee, Surya; Villasenor, Andrew; Sheldon, Jessica R.; Paudel, Pratikshya; Rajput, Ravindra

doi:10.1016/j.vas.2022.100279

Cited by 11 publications

(8 citation statements)

References 74 publications

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“…Although previous studies have shown that obesity is associated with a high ratio of Firmicutes to Bacteroidetes [76], the interaction between host nutrient absorption and gut microbial composition is extremely complex and not directly related to the ratio of Firmicutes to Bacteroidetes [77]. Rajput et al [78] found that the IgA level was negatively correlated with the ratio of Firmicutes to Bacteroidetes. The IgA level was negatively correlated with the abundance of Firmicutes and positively correlated with the abundances of Bacteroidetes and Desulfobacterota, which indicates that a higher Firmicutes/Bacteroidetes ratio may be associated with poor mucosal humoral immunity.…”

Section: Discussionmentioning

confidence: 99%

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Zhang,

Shu,

et al. 2023

Animals

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(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way to solve the current dilemma and promote the pig industry. (2) Methods: to assess the effects of a fermented Chinese herbal (FCH) formula on the growth and immunity of growing pigs, 100 Duroc × Landrace × Yorshire three-way crossed growing pigs were randomly divided into control and treatment groups that were fed a basal diet, and a basal diet with 1% (group A), 2% (group B), and 3% (group C) FCH formulas, respectively. A sixty-day formal experiment was conducted, and their growth and serum indices, colonic microbiota, and metabolites were analyzed. (3) Results: the daily gain of growing pigs in groups A, B, and C increased by 7.93%, 17.68%, and 19.61%, respectively, and the feed-to-gain ratios decreased by 8.33%, 15.00%, and 14.58%, respectively. Serum immunity and antioxidant activities were significantly increased in all treatment groups. Particularly, adding a 2% FCH formula significantly changed the colon’s microbial structure; the Proteobacteria significantly increased and Firmicutes significantly decreased, and the metabolite composition in the colon’s contents significantly changed. (4) Conclusions: these results indicate that the FCH formula is a good feed additive for growing pigs, and the recommended addition ratio was 3%.

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Section: Discussionmentioning

confidence: 99%

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Zhang,

Shu,

et al. 2023

Animals

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“…People living in ICT (Islamabad Capital Territory) showed higher abundance of Desulfobacterota in comparison to other provinces of residence. Desulfobacterota are sulfate-reducing bacteria, associated with gut inflammation and increased immune response [ 24 ]. Moreover, lower abundance of Firmicutes and higher abundance of Bacteriodota was observed in males as compared to females.…”

Section: Discussionmentioning

confidence: 99%

Gut microbial ecology and exposome of a healthy Pakistani cohort

Gul,

Herrema,

Davids

et al. 2024

Gut Pathog

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Background Pakistan is a multi-ethnic society where there is a disparity between dietary habits, genetic composition, and environmental exposures. The microbial ecology of healthy Pakistani gut in the context of anthropometric, sociodemographic, and dietary patterns holds interest by virtue of it being one of the most populous countries, and also being a Lower Middle Income Country (LMIC). Methods 16S rRNA profiling of healthy gut microbiome of normo-weight healthy Pakistani individuals from different regions of residence is performed with additional meta-data collected through filled questionnaires. The current health status is then linked to dietary patterns through $${\chi }^{2}$$ χ 2 test of independence and Generalized Linear Latent Variable Model (GLLVM) where distribution of individual microbes is regressed against all recorded sources of variability. To identify the core microbiome signature, a dynamic approach is used that considers into account species occupancy as well as consistency across assumed grouping of samples including organization by gender and province of residence. Fitting neutral modeling then revealed core microbiome that is selected by the environment. Results A strong determinant of disparity is by province of residence. It is also established that the male microbiome is better adapted to the local niche than the female microbiome, and that there is microbial taxonomic and functional diversity in different ethnicities, dietary patterns and lifestyle habits. Some microbial genera, such as, Megamonas, Porphyromonas, Haemophilus, Klebsiella and Finegoldia showed significant associations with consumption of pickle, fresh fruits, rice, and cheese. Our analyses suggest current health status being associated with the diet, sleeping patterns, employment status, and the medical history. Conclusions This study provides a snapshot of the healthy core Pakistani gut microbiome by focusing on the most populous provinces and ethnic groups residing in predominantly urban areas. The study serves a reference dataset for exploring variations in disease status and designing personalized dietary and lifestyle interventions to promote gut health, particularly in LMICs settings.

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“…People living in ICT (Islamabad Capital Territory) showed higher abundance of Desulfobacterota in comparison to other provinces of residence. Desulfobacterota are sulfate-reducing bacteria, associated with gut in ammation and increased immune response (24). Moreover, lower abundance of Firmicutes and higher abundance of Bacteriodota was observed in males as compared to females.…”

Section: Discussionmentioning

confidence: 99%

Gut microbial ecology and exposome of a healthy Pakistani cohort

Gul,

Herrema,

Davids

et al. 2023

Preprint

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Background: Pakistan is a multi-ethnic society where there is a disparity between dietary habits, genetic composition, and environmental exposures. The microbial ecology of healthy Pakistani gut in the context of anthropometric, sociodemographic, and dietary patterns holds interest by virtue of it being one of the most populous countries, and also being a Lower Middle Income Country (LMIC). Methods: 16S rRNA profiling of healthy gut microbiome of normo-weight healthy Pakistani individuals from different regions of residence is performed with additional meta-data collected through filled questionnaires. The current health status is then linked to dietary patterns through χ2 test of independence and Generalized Linear Latent Variable Model (GLLVM) where distribution of individual microbes is regressed against all recorded sources of variability. To identify the core microbiome signature, a dynamic approach is used that considers into account species occupancy as well as consistency across assumed grouping of samples including organization by gender and province of residence. Fitting neutral modeling then revealed core microbiome that is selected by the environment. Results: A strong determinant of disparity is by province of residence. It is also established that the male microbiome is better adapted to the local niche than the female microbiome, and that there is microbial taxonomic and functional diversity in different ethnicities, dietary patterns and lifestyle habits. Conclusions: This study provides a snapshot of the healthy core Pakistani gut microbiome by focusing on the most populous provinces and ethnic groups residing in predominantly urban areas. The study serves a reference dataset for exploring variations in disease status and designing personalized dietary and lifestyle interventions to promote gut health, particularly in LMICs settings.

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Determining the association between gut microbiota and its metabolites with higher intestinal Immunoglobulin A response

Cited by 11 publications

References 74 publications

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites

Gut microbial ecology and exposome of a healthy Pakistani cohort

Gut microbial ecology and exposome of a healthy Pakistani cohort

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