Determining fouling‐independent component of critical flux in protein ultrafiltration using the free‐solvent‐based (FSB) model

Wang, Yiheng; Rodgers, V.G.J.

doi:10.1002/aic.12152

Cited by 25 publications

(8 citation statements)

References 19 publications

(12 reference statements)

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“…For a given protein surface potential, at each chosen pressure, the permeate flux is calculated through the iteration on C w , until J v calculated from Eqs. (20) and (1) respectively reaches agreement.…”

Section: Modified Fsb Model Simulation Methodssupporting

confidence: 70%

“…(20), P elec is evaluated at the membrane surface only, with the distance between two proteins, d 0 , approximately calculated from the protein wall concentration, C w :…”

Section: Modified Fsb Model Simulation Methodsmentioning

confidence: 99%

“…We have recently shown that, when osmotic pressure contributions in the concentrated region are correctly addresses, they directly predict the non-linear flux behavior observed in limiting flux [19] and provided exceptional predictions for critical flux [20]. This is because the free-solvent-based (FSB) model [19] incorporates the significant contribution of hydration to the osmotic pressure [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrostatic contributions to permeate flux behavior in single bovine serum albumin ultrafiltration

Wang

Rodgers

2011

Journal of Membrane Science

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Section: Modified Fsb Model Simulation Methodssupporting

confidence: 70%

“…(20), P elec is evaluated at the membrane surface only, with the distance between two proteins, d 0 , approximately calculated from the protein wall concentration, C w :…”

Section: Modified Fsb Model Simulation Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrostatic contributions to permeate flux behavior in single bovine serum albumin ultrafiltration

Wang

Rodgers

2011

Journal of Membrane Science

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“…[46][47][48][49][50][51] However, we have shown that, via our FSB model, the bulk property, osmotic pressure, of self-crowded proteins and crowded binary globular protein solutions can directly provide ion binding and hydration properties of proteins, specifically in the highly crowded regions where the rate of change of osmotic pressure to protein concentration is highly non-linear. [52][53][54][55][56][57][58][59][60][61][62][63] Because the FSB model focuses on protein hydration and ion-binding, it can provide a fortuitous approach in interrogating anion effects on crowded protein solutions.…”

Section: Relevance Of Osmotic Pressure In the Interpretation Of Anionmentioning

confidence: 99%

Interrogating the Osmotic Pressure of Self-Crowded Bovine Serum Albumin Solutions: Implications of Specific Monovalent Anion Effects Relative to the Hofmeister Series

et al. 2018

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The free-solvent-based (FSB) model and osmotic pressure were used to probe the ion binding and protein hydration for self-crowded bovine serum albumin in 0.15 M NaF, NaCl, NaI, and NaSCN solutions. All experiments were conducted with solutions at pH 7.4. The regressed results of the FSB model behavior to the measured osmotic pressure were excellent, albeit, the osmotic pressure data for NaSCN were noisy. The resulting ion binding and hydration were realistic values and the covariance of the two parameters was exceptionally low, providing substantial credibility to the FSB model. The results showed that the kosmotropic F and neutral Cl solutions generated significantly higher ion binding and protein hydration than the chaotropic solutions of I and SCN. Further, the ionic strength ratio and resulting hydration implied that the chaotropic solutions had substantially higher aggregation than the other salts investigated. Overall, the FSB model provides an additional, complementary tool to contribute to the analysis of crowded protein solutions relative to anions in the Hofmeister series as it can interrogate crowded solutions directly; something that is not possible with many measurement techniques.

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“…Equation (2) was later used by Person and Denn (1997) in a study of the flow of a powerlaw fluid in a channel. The slip equation proposed by Wang et al (2010) includes an additional exponential term accounting for temperature effects. Similarly, Hatzikiriakos and Dealy (1992) formulated a theoretical model based on an extension of analysis of Lau and Schowalter (1986), which, despite its different theoretical basis, was of form similar to that of Eq.…”

Section: Introductionmentioning

confidence: 99%

Newtonian Poiseuille flows with pressure-dependent wall slip

Panaseti

Housiadas

Georgiou

2013

Journal of Rheology

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The effect of pressure-dependent slip at the wall in steady, isothermal, incompressible Poiseuille flows of a Newtonian liquid is investigated. Exponential dependence of the slip coefficient on the pressure is assumed and the flow problems are solved using a regular perturbation scheme in terms of the exponential decay parameter of the slip coefficient. The sequence of partial differential equations resulting from the perturbation procedure is solved analytically up to second order. The two-dimensional solution reveals the effects of the slip decay coefficient and the other dimensionless numbers and parameters, in the flow. The average pressure drop and the skin friction factor are also derived and discussed. V

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Determining fouling‐independent component of critical flux in protein ultrafiltration using the free‐solvent‐based (FSB) model

Cited by 25 publications

References 19 publications

Electrostatic contributions to permeate flux behavior in single bovine serum albumin ultrafiltration

Electrostatic contributions to permeate flux behavior in single bovine serum albumin ultrafiltration

Interrogating the Osmotic Pressure of Self-Crowded Bovine Serum Albumin Solutions: Implications of Specific Monovalent Anion Effects Relative to the Hofmeister Series

Newtonian Poiseuille flows with pressure-dependent wall slip

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